Author: Fiona Craig

  • Oil holds above $110 as Middle East tensions fuel strong March surge

    Oil holds above $110 as Middle East tensions fuel strong March surge

    Oil prices remained above $110 per barrel on Tuesday as investors weighed reports of a tanker fire near Dubai against indications that U.S. President Donald Trump may be considering winding down military operations against Iran.

    As of 04:49 ET (08:49 GMT), Brent crude futures for May delivery, the global benchmark, edged up 0.1% to $112.87 per barrel, while West Texas Intermediate (WTI) futures fell 0.4% to $102.49 per barrel.

    Crude prices initially spiked earlier in the session after a Kuwaiti oil tanker caught fire near Dubai’s port area. The vessel’s owner said the blaze was the result of an Iranian attack.

    However, gains eased somewhat after a Wall Street Journal report said Trump had told advisers he might be willing to end the military campaign against Iran even if the Strait of Hormuz remains closed. According to the report, Trump and his team believe that reopening the crucial waterway would likely take far longer than the four-to-six-week timeline originally envisioned for the conflict.

    Instead, Washington may seek to reduce hostilities after achieving its primary objectives, including weakening Iran’s naval capabilities and damaging its missile systems. The U.S. would then try to persuade Tehran through diplomatic channels to reopen the strait and could also encourage European and Gulf allies to take the lead in restoring shipping access.

    A potential reduction in U.S. military activity could mark a step toward de-escalation, particularly as Iranian officials have previously demanded such a move before engaging in direct negotiations with Washington.

    Nevertheless, a prolonged shutdown of the Strait of Hormuz would continue to threaten global oil supplies, given that around 20% of the world’s crude passes through the narrow passage.

    Oil on track for one of its largest monthly gains

    Both Brent and WTI crude were heading for a dramatic increase in March, with prices projected to rise between 50% and 54%, representing one of the strongest monthly performances on record.

    The rally reflects growing risk premiums and fears of supply disruptions tied to the conflict with Iran. Tehran has effectively blocked the Strait of Hormuz and has targeted oil tankers and energy infrastructure in neighboring Persian Gulf states, intensifying concerns about sustained disruptions to crude supply.

    Several Gulf nations have temporarily halted oil production and exports over the past month as the conflict escalated.

    Conflicting signals about the state of the war have also contributed to market volatility. Iranian officials have repeatedly stated that no direct talks with the United States have taken place since the conflict began, contradicting claims from Washington that negotiations were progressing.

    Meanwhile, the United States has reportedly deployed thousands of additional troops to the Middle East. President Trump has also reiterated threats to strike Iran’s energy infrastructure and potentially water facilities if the Strait of Hormuz is not reopened by April 6.

    Diplomatic efforts to ease tensions are ongoing, with Pakistan offering to host regional ceasefire negotiations in Islamabad.

    Over the weekend, Yemen’s Iran-backed Houthi movement entered the conflict by launching attacks against Israel, raising concerns that the war could widen further, particularly given the group’s ability to target vessels traveling through the Red Sea.

  • Eurozone inflation rises to 2.5% in March as Iran conflict drives energy costs higher

    Eurozone inflation rises to 2.5% in March as Iran conflict drives energy costs higher

    Inflation across the Eurozone picked up in March as energy prices surged amid the conflict in Iran, though the increase came in slightly below economists’ expectations.

    Consumer prices across the 21 countries using the euro rose 2.5% year-on-year in March, up from 1.9% in February, a month that largely preceded the escalation of fighting in the Middle East. Economists had forecast inflation at 2.6%.

    Even so, the figure remained well above the European Central Bank’s 2% inflation target. ECB officials have recently indicated that interest rate increases could be considered as policymakers respond to the inflationary impact of the joint U.S.-Israeli military action against Iran that began in late February.

    The sharp rise in oil and gas prices has been one of the defining features of the conflict. Eurozone energy costs climbed 4.9% in March, reflecting disruptions linked to the war. The effective shutdown of the Strait of Hormuz — a key shipping route off Iran’s southern coast through which roughly one-fifth of the world’s oil supply passes — has restricted global energy flows.

    Europe has also grown more dependent on natural gas imports from the Persian Gulf since Russia’s invasion of Ukraine in 2022. Production facilities in the region have recently been targeted by Iranian air strikes, adding further uncertainty to energy markets.

    While the ECB would typically look through temporary price shocks, ECB President Christine Lagarde has indicated that policymakers are prepared to react even if inflationary pressures prove only moderately persistent. Officials are particularly concerned that the spike in energy prices could feed into broader inflation across the economy.

    Prices for services — a key component of Eurostat’s inflation data and an important driver of domestic price pressures — eased slightly, rising 3.2% in March compared with 3.4% the previous month.

    The ECB, which is scheduled to meet again on April 30, is now widely expected to raise interest rates three times this year, with the first increase potentially coming as soon as next month or in June.

    “[T]he longer the shock lasts, the higher the risk of second-round effects causing broader elevated inflation,” said Bert Colijn, Chief Economist, Netherlands, at ING in a note.

    “[L]ooking ahead, you cannot see the energy price increase in isolation. It’s all about the Middle East, which dominates the inflation outlook, and not just when it comes to energy prices, but also expect upside risk to food and goods prices given fertiliser shortages and broader supply chain problems stemming from the war.”

  • Getlink shares climb more than 4% as Mundys plans to lift stake to 25%

    Getlink shares climb more than 4% as Mundys plans to lift stake to 25%

    Shares of Getlink (EU:GET) gained over 4% on Tuesday after Italian infrastructure group Mundys announced plans to increase its holding in the cross-Channel transport operator to as much as 25%, subject to regulatory clearance.

    Mundys said Monday that it will immediately acquire 3.5% of Getlink’s share capital, while securing an option to purchase a further 6%, pending approval from the UK government under the National Security and Investment Act 2021. That decision is expected by April.

    The investment will be executed through Mundys’ wholly owned subsidiary, Aero 1 Global & International S.à r.l.

    Once the initial transaction is completed, Mundys will own 19% of Getlink’s share capital and up to 24.9% of its voting rights. If regulatory approval is granted, the group’s stake could increase to 25% of the company’s capital and up to 29.9% of voting rights.

    These figures are based on Getlink’s capital structure of 550 million shares and 699,916,029 voting rights, as reported on March 11.

    Mundys also noted it could consider further purchases depending on market conditions, though it emphasized that it has no plans to take control of the company or seek additional board representation. The group said the move builds on its long-term partnership with Getlink, which began in 2018.

    Mundys, controlled by Edizione with Blackstone as its second-largest shareholder, operates motorway and airport concessions in 24 countries. France represents its biggest market, accounting for 28% of EBITDA in 2025.

  • Gold rebounds slightly as markets watch Iran tensions; still set for sharp March losses

    Gold rebounds slightly as markets watch Iran tensions; still set for sharp March losses

    Gold prices moved higher during Asian trading on Tuesday, drawing some renewed buying interest after suffering steep declines throughout March as rising inflation expectations tied to the U.S.–Israel conflict with Iran pressured non-yielding assets such as precious metals.

    Metals markets were also supported by reports that U.S. President Donald Trump is considering scaling back military operations against Iran, as the conflict appears likely to stretch beyond the four-to-six-week timeframe initially anticipated.

    Additional support came after Federal Reserve Chair Jerome Powell said long-term inflation expectations remain well anchored despite potential short-term disruptions.

    Spot gold rose 1% to $5,556.54 per ounce at 01:17 ET (05:17 GMT), while gold futures gained 0.6% to $4,587.01 per ounce.

    Other precious metals also strengthened on Tuesday. Spot silver climbed 2.7% to $71.9805 per ounce, while spot platinum increased 0.8% to $1,914.85 per ounce, although both metals remain on track to record sizable losses for the month of March.

    Trump may end Iran campaign without reopening Hormuz – WSJ

    According to a report by the Wall Street Journal on Monday evening, Trump told advisers he could be willing to conclude the military campaign against Iran even if the Strait of Hormuz remains closed.

    Officials cited in the report believe that an operation to fully reopen the strait would likely extend the conflict beyond the president’s initial timeline and could require a complicated military effort.

    Instead, Trump is said to believe the U.S. could begin winding down hostilities after achieving core objectives, including weakening Iran’s naval strength and degrading its missile capabilities.

    Washington would then attempt to pressure Tehran through diplomatic channels to reopen the strait, while also encouraging European and Gulf allies to take the lead in restoring maritime access.

    The report raised some optimism that the conflict might eventually ease, although a continued closure of the Strait of Hormuz — which carries roughly 20% of global oil supply — would likely keep energy prices and inflation concerns elevated.

    Gold heading for worst month in nearly two decades

    Despite Tuesday’s modest rebound, gold prices remain on course for their weakest monthly performance in almost 20 years.

    Spot gold was down about 14% in March, which would also end a seven-month streak of gains for the precious metal.

    The metal has come under pressure as investors reassess expectations for further interest rate cuts from the Federal Reserve. The surge in oil prices following the outbreak of the Iran conflict has boosted inflation expectations, dampening hopes for monetary easing.

    At the same time, several major central banks — including the European Central Bank and the Bank of Japan — have indicated that interest rate hikes could be considered to counter energy-driven inflation, pushing bond yields higher and reducing the appeal of non-yielding assets like gold.

    These pressures have also weighed on other precious metals. Spot silver has fallen roughly 23% this month, while platinum is on track to drop about 19% in March.

  • Futures climb while oil stays elevated amid Iran conflict — markets watch key data: Dow Jones, S&P, Nasdaq, Wall Street

    Futures climb while oil stays elevated amid Iran conflict — markets watch key data: Dow Jones, S&P, Nasdaq, Wall Street

    U.S. equity futures moved higher on Tuesday as investors approached the final trading session of the first quarter, helped by reports suggesting that President Donald Trump may be considering ending the military campaign against Iran even if the Strait of Hormuz remains largely blocked. Energy markets, however, remained tense after a Kuwaiti oil tanker caught fire near Dubai following what its owner described as an Iranian strike. Traders are also looking ahead to fresh U.S. labor market data and new inflation figures from the Eurozone.

    U.S. futures point higher

    U.S. stock futures were trading in positive territory early Tuesday as the conflict involving Iran continued to shape global market sentiment.

    At 03:29 ET, Dow futures were up 333 points, or 0.7%, S&P 500 futures had added 42 points, or 0.7%, and Nasdaq 100 futures rose 137 points, or 0.6%.

    Monday’s trading session on Wall Street ended unevenly. The S&P 500 and Nasdaq Composite both finished lower, while the Dow Jones Industrial Average managed a small gain.

    Earlier optimism had lifted equities after President Trump wrote on social media that negotiations with Iran were making “great progress.” At the same time, he reiterated that the United States could strike Iranian power plants and other key infrastructure if talks fail to reopen the Strait of Hormuz.

    “While Trump and the White House are trying to put a very positive spin on the state of negotiations, investors are paying much more attention to actual developments in the war,” analysts at Vital Knowledge said in a note to clients.

    Fighting in the Middle East has intensified in recent days, with continued air strikes and the involvement of Iran-aligned Houthi forces in Yemen. The widening conflict has heightened concerns over potential disruptions to global oil shipping routes. Tehran has also rejected Washington’s claims about progress in talks and largely dismissed a 15-point U.S. peace proposal.

    Trump reportedly considering ending Iran campaign without reopening Hormuz

    According to a report by the Wall Street Journal, Trump has told advisers he could wrap up the military campaign against Iran even if the Strait of Hormuz remains mostly closed.

    Officials cited by the newspaper said attempts to fully reopen the waterway would likely extend the conflict beyond the four-to-six-week timeframe initially envisioned by the administration. Instead, Washington may aim to scale down hostilities after achieving major objectives such as weakening Iran’s naval forces and limiting its missile arsenal.

    The U.S. would then attempt to persuade Iran diplomatically to restore access to the strait. If that approach fails, Washington may encourage European and Gulf allies to take the lead in reopening the key shipping route.

    The Strait of Hormuz has become a focal point of the U.S.-Israel confrontation with Iran. Tehran has effectively obstructed the channel using naval mines and missile strikes. The passage is critical to global energy markets, carrying roughly 20% of the world’s oil consumption.

    Oil holds above $110

    Disruptions to traffic through the strait have triggered a sharp rise in global energy prices over the past several weeks.

    Brent crude, the global benchmark, has surged above $110 per barrel, compared with around $70 before the conflict began. On Tuesday, May Brent futures were up 0.5% at $113.39 per barrel.

    Adding further pressure to prices, a Kuwaiti tanker caught fire near Dubai after what the vessel’s owner said was an Iranian attack. Since the conflict began in late February, Iran has targeted energy facilities across the Persian Gulf, raising fears of supply disruptions affecting countries in both Asia and Europe.

    Meanwhile, Iran’s parliament has reportedly approved an early proposal to impose a toll on ships transiting the Strait of Hormuz, according to the semi-official Fars news agency.

    “A toll or selective access through Hormuz would keep a persistent risk premium in oil, as flows could be curtailed at short notice, while higher insurance and freight costs lift delivery prices even without a full shutdown,” analysts at ING said in a note.

    JOLTS report in focus

    On the economic calendar, markets will be watching the latest Job Openings and Labor Turnover Survey (JOLTS) from the United States, widely viewed as a gauge of labor demand.

    Economists expect the report to show 6.89 million job openings in February, slightly lower than 6.946 million in January.

    Although the data largely covers a period before the escalation of tensions in the Middle East, it remains an important measure of labor market strength before the geopolitical shock. The report will also serve as a lead-in to Friday’s more comprehensive March nonfarm payrolls report.

    Officials at the Federal Reserve will closely monitor the employment data, particularly as inflation pressures begin to build. Employment and inflation remain the two key pillars guiding the Fed’s policy decisions.

    Eurozone inflation data ahead

    Investors are also awaiting Eurozone inflation figures for March, which could provide further insight into the economic consequences of the Middle East conflict.

    Europe relies heavily on natural gas imports from Gulf countries, especially Qatar, where production facilities have reportedly been targeted by Iranian air strikes.

    Officials at the European Central Bank (ECB) have indicated that rate hikes could be considered if higher energy costs revive inflation across the currency bloc. ECB President Christine Lagarde has said policymakers may still need to act even if price pressures prove temporary.

    Economists expect headline inflation to reach 2.6% in March, up from 1.9% in February. The ECB’s medium-term inflation target remains 2.0%.

    Expectations of a possible ECB rate increase have pushed European government bond yields higher in recent sessions, although they were largely stable ahead of Tuesday’s inflation release. Bond yields typically move in the opposite direction to bond prices.

  • European stocks trade cautiously as Iran war continues and inflation data approaches: DAX, CAC, FTSE100

    European stocks trade cautiously as Iran war continues and inflation data approaches: DAX, CAC, FTSE100

    European equity markets moved in a narrow range on Tuesday, hovering close to flat even as oil prices continued their sharp surge. Sentiment was somewhat supported by reports that U.S. President Donald Trump may be prepared to wind down the conflict with Iran even if the Strait of Hormuz remains largely closed.

    By 07:10 GMT, the pan-European Stoxx 600 index was up about 0.1%. Germany’s DAX had gained 0.2%, the UK’s FTSE 100 edged 0.1% higher, and France’s CAC 40 was broadly unchanged.

    According to a report from the Wall Street Journal, Trump has signaled openness to bringing the more than month-long military campaign against Iran to a close even if Tehran maintains effective control over the Strait of Hormuz. The strategic waterway carries roughly one-fifth of global oil shipments, and its disruption for several weeks has triggered a sharp rise in energy prices while increasing recession concerns worldwide.

    Brent crude futures, the global benchmark for oil, were trading above $110 per barrel, compared with roughly $70 before the conflict began.

    The report said Trump and his advisers concluded that a full effort to reopen the strait would extend the military campaign beyond the four-to-six-week timeframe initially envisioned. Instead, the administration has reportedly opted to target Iran’s naval forces and missile capabilities while seeking to gradually reduce hostilities and intensify diplomatic pressure on Tehran. U.S. officials added that Washington could also rely on European and Gulf allies to address the strait if negotiations fail.

    Markets may receive additional signals about the economic consequences of the Middle East conflict later in the day with the release of Eurozone inflation figures for March. The regional conflict, which has expanded beyond a joint U.S.–Israeli offensive against Iran to involve several countries across the Middle East, has raised concerns about energy supply disruptions.

    Europe depends heavily on natural gas imports from Gulf countries, particularly Qatar, where energy infrastructure has reportedly been targeted in Iranian air strikes.

    Officials at the European Central Bank (ECB) have indicated that interest rate increases may become necessary if the surge in energy prices reignites inflation across the Eurozone. ECB President Christine Lagarde has suggested policymakers may still need to respond even if the rise in prices proves temporary.

    Economists currently forecast that headline consumer inflation in the Eurozone will increase to 2.6% in March, up from 1.9% in February. The ECB’s medium-term inflation objective remains 2.0%.

    Anticipation of potential ECB tightening has pushed European government bond yields higher in recent sessions, although yields were largely steady ahead of Tuesday’s inflation release. Bond yields typically move in the opposite direction of bond prices.

  • Energy shock and slower growth revive stagflation concerns for European equities: Goldman Sachs

    Energy shock and slower growth revive stagflation concerns for European equities: Goldman Sachs

    Goldman Sachs says the risk of stagflation has returned to the discussion around European equities, as rising energy prices linked to the Middle East conflict combine with weaker economic growth forecasts across the region.

    According to the bank’s strategists, the geopolitical tensions have shifted the macroeconomic backdrop away from the previously favourable “Goldilocks” environment. Goldman’s commodities team has increased its energy price projections, now expecting Brent crude to average $80 per barrel in the fourth quarter of 2026, compared with $60 before the conflict. European gas prices are also forecast higher, with TTF expected at €40 per megawatt-hour, up from the earlier €30 estimate.

    At the same time, Goldman’s economists have downgraded their outlook for eurozone growth. GDP is now projected to expand 0.7% year-on-year in the fourth quarter, down from the 1.4% forecast before the conflict. Inflation expectations have also moved higher, with headline inflation now predicted to reach 3.2% by the second quarter, compared with the previous 2% estimate.

    In response to these developments, central banks have adopted a more hawkish stance. The European Central Bank is now expected by markets to deliver three rate hikes this year, whereas prior to the conflict interest rate expectations had been broadly stable.

    Goldman does not yet view stagflation as its base-case scenario, but warns that the risk profile has deteriorated. The bank noted that “the balance of risks has worsened and the probability of a stagflationary outcome has increased.” Strategists also highlighted that macroeconomic sensitivities tend to be non-linear, meaning downside risks could intensify if disruptions to shipping through the Strait of Hormuz persist.

    Historically, stagflationary periods have been difficult for equity markets. Goldman’s analysis shows that the median real quarterly return for the STOXX 600 drops to around -1% during stagflation, compared with +3% in other economic environments.

    “Stagflation exerts a double pressure on equities by (1) compressing fundamentals via margin pressure and (2) compressing valuations via higher rates and a more uncertain earnings outlook,” strategists led by Guillaume Jaisson said in a note.

    Despite the growing risks, the bank believes equity markets have not fully priced in a stagflation scenario. While sector rotation has started to resemble a typical stagflation pattern — with Energy, Value stocks and Defensive sectors outperforming Growth and Cyclical names — the overall level of major indices suggests investors still expect the shock to remain manageable.

    “Sharp policy repricing has created a regime within a regime,” the strategists wrote, adding that the current environment is producing sudden and sometimes non-linear sector shifts that make it difficult to identify consistent winners and losers.

    From a positioning perspective, Goldman continues to favour a defensive approach. The bank is overweight Telecoms and Consumer Staples, while underweighting Consumer Discretionary, Autos and Chemicals.

    It also sees opportunities in Defence and Fiscal Infrastructure, and continues to view European banks as an attractive value play for investors who believe stagflation risks will ultimately fade, citing resilient earnings profiles and strong income characteristics.

  • FTSE 100 today: UK shares inch higher as Trump reportedly signals Iran conflict wind-down

    FTSE 100 today: UK shares inch higher as Trump reportedly signals Iran conflict wind-down

    UK equities moved slightly higher on Tuesday after reports that U.S. President Donald Trump may be open to ending military operations against Iran even if the Strait of Hormuz remains largely closed. The pound strengthened modestly, while European markets showed mixed performance. Meanwhile, fresh data confirmed the UK economy expanded by 0.1% quarter-on-quarter in the final quarter of 2025.

    By 07:25 GMT, the benchmark FTSE 100 index was up about 0.2%, while the pound gained 0.1% against the dollar, with GBP/USD trading near 1.3202. In continental Europe, Germany’s DAX advanced 0.1%, whereas France’s CAC 40 slipped 0.2%.

    According to a report from the Wall Street Journal, Trump has told senior officials he would consider concluding military operations against Iran even if the Strait of Hormuz remains largely obstructed. The report said the administration believes attempting to fully reopen the strategic shipping route could extend the conflict well beyond the preferred four-to-six-week timeframe. Officials indicated the White House may now favour scaling back hostilities after achieving key objectives, including weakening Iran’s naval forces and reducing its missile capabilities.

    UK economic update

    Final GDP figures released Tuesday showed the UK economy grew by 0.1% quarter-on-quarter in Q4 2025, matching the preliminary estimate. The data indicated that public sector activity increased while private sector output declined during the period.

    Consumer spending rose only 0.1% quarter-on-quarter, revised down from an earlier estimate of 0.2%. Business investment fell 2.5%, slightly better than the previous estimate of a 2.7% decline. Net trade reduced GDP growth by 0.5 percentage points. After rounding adjustments, overall economic growth for 2025 was revised slightly higher to 1.4%, up from the previously reported 1.3%.

    Corporate news roundup

    Raspberry Pi Holdings PLC (LSE:RPI) reported a 25% increase in full-year adjusted EBITDA, supported by resilient demand despite higher product prices linked to rising memory costs. The Cambridge-based computing platform developer recorded adjusted EBITDA of $46.4 million for the year ended December 31, 2025, compared with $37.2 million a year earlier. Revenue climbed 25% to $323.2 million, up from $259.5 million.

    A.G.Barr PLC (LSE:BAG) delivered adjusted pretax profit of £65.8 million for the year ended January 31, representing a 12.5% increase from the previous year and slightly exceeding analysts’ expectations of £65.4 million, according to LSEG data. Revenue rose 4% to £437.3 million, while adjusted earnings per share reached 44.24 pence. The maker of Irn-Bru said growth in energy and health drinks helped offset higher costs linked to the Middle East conflict.

    Severfield PLC (LSE:SFR) said it expects pretax profit for the financial year ending March 2026 to come in around £10.2 million, broadly matching market forecasts. The structural steel specialist also reported net debt of about £28 million, significantly below the consensus estimate of £48.5 million, reflecting strong cash management.

    Future PLC (LSE:FUTR) lowered its full-year outlook by 15% to 20% as the company adjusts to a sharper-than-expected drop in traffic originating from Google. The Bath-based media group said direct advertising revenue should still grow year-on-year, while declines at Go.Compare and its B2B segment moderated during the first half and are expected to turn to growth in the second half.

    Hilton Food Group Plc (LSE:HFG) reported full-year adjusted pretax profit of £73 million for fiscal 2025, in line with previous guidance. The food packaging and supply specialist reiterated its FY26 adjusted PBT forecast of £60–65 million and announced a strategic review aimed at strengthening its core red meat operations while improving efficiency and margins.

    3i Infrastructure PLC (LSE:3IN) also released a portfolio update covering the period from October 1, 2025, to March 30, 2026, stating it remains on track to meet its full-year return objective. The company expects portfolio returns of 8–10%, with strong performance from FLAG supported by continued demand for subsea data connectivity driven by AI workloads.

  • AstraZeneca reports mixed Phase III outcomes for HPP therapy efzimfotase alfa

    AstraZeneca reports mixed Phase III outcomes for HPP therapy efzimfotase alfa

    AstraZeneca (LSE:AZN) released results from three Phase III clinical studies evaluating efzimfotase alfa, an experimental treatment for hypophosphatasia (HPP), a rare inherited disorder that affects bone development.

    The MULBERRY study, which involved treatment-naive children aged 2 to 12, achieved its primary objective. Patients receiving efzimfotase alfa showed a statistically significant improvement in bone health versus placebo at week 25, measured using the Radiographic Global Impression of Change score.

    Results from the CHESTNUT trial showed that pediatric patients who transitioned from the current therapy Strensiq to efzimfotase alfa were able to maintain treatment benefits. The study also indicated that the new therapy demonstrated acceptable safety and tolerability.

    However, the HICKORY trial, which evaluated adolescents and adults aged 12 and above, did not meet its primary endpoint. The study failed to show a statistically significant improvement in the Six-Minute Walk Test compared with placebo. AstraZeneca said this was largely due to stronger-than-anticipated outcomes in the placebo group among adults with late-onset HPP. Despite this, the treatment delivered nominally significant improvements in fatigue across the overall study population and showed positive effects on mobility and physical functioning in predefined subgroups of patients with pediatric-onset disease.

    In total, the clinical programme enrolled 196 participants across 22 countries, marking the first trials designed to include both pediatric-onset and adult-onset HPP patients.

    Efzimfotase alfa is being developed as an enzyme replacement therapy intended to reduce treatment burden by requiring smaller injection volumes and less frequent dosing than the currently available therapy Strensiq.

    AstraZeneca said the findings will be presented at an upcoming medical conference and will also be submitted to regulators worldwide. The therapy was developed by Alexion, AstraZeneca’s rare disease division.

  • Ashmore Group forms strategic partnership with Japan Post Insurance

    Ashmore Group forms strategic partnership with Japan Post Insurance

    Ashmore Group PLC (LSE:ASHM) announced on Tuesday that it has entered into a strategic partnership with Japan Post Insurance, which includes a $1 billion investment commitment to its emerging markets funds along with the purchase of an equity stake in the company.

    As part of the agreement, Japan Post Insurance plans to allocate $1 billion across a selection of Ashmore’s emerging markets investment strategies. The capital will be deployed gradually over roughly 12 months rather than being invested all at once.

    In addition to the fund investment, Japan Post Insurance intends to build a 2.9% shareholding in Ashmore Group through purchases in the open market. The company did not provide a timeline for when those share acquisitions will take place.