Author: Fiona Craig

Hemogenyx Pharmaceuticals (LSE:HEMO) has reported progress in its Phase I clinical trial of HG-CT-1, a CAR-T therapy for relapsed or refractory acute myeloid leukemia (AML) in adults. The company confirmed that the third patient treated in the study met the required safety benchmarks and showed encouraging early results, with no detectable AML cells following treatment. The trial is designed as a dose-escalation study, assessing safety as the primary endpoint, while also monitoring efficacy and survival outcomes. These initial findings highlight the therapy’s potential to address a serious unmet medical need and strengthen Hemogenyx’s position in the fight against aggressive forms of leukemia.

About Hemogenyx Pharmaceuticals Plc

Hemogenyx Pharmaceuticals is a clinical-stage biopharmaceutical company headquartered in London, with subsidiaries in New York. The company is focused on developing novel therapies for blood and autoimmune diseases, leveraging proprietary product candidates and platform technologies to advance innovative treatment options.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

TruFin plc (LSE:TRU) has announced a sharp increase in financial performance for the first half of 2025, with gross revenue rising 42% year-on-year to £36.0 million. Profit before tax surged to £4.6 million, representing a remarkable 2,711% increase. The strong results were powered by Playstack, which recorded a 52% revenue uplift thanks to successful new game launches, and by Oxygen Finance, which continues to benefit from steady recurring revenues. By contrast, Satago Financial Solutions reported weaker performance following the loss of a key contract, leading to reduced revenues.

The company also completed a share repurchase program during the period and outlined plans to sustain momentum through further strategic investments and upcoming game releases.

TruFin’s outlook is supported by its robust financial results and favorable corporate developments, with technical indicators pointing to a bullish trend. However, valuation concerns modestly limit the strength of the overall assessment.

About TruFin plc

TruFin plc is the parent company of three technology-driven businesses operating in specialized markets, including early payment services, invoice financing, and video game publishing. The company was admitted to London’s AIM market in February 2018.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

City of London Investment Trust PLC (LSE:CTY) has posted a net asset value total return of 16.8% for the year ending 30 June 2025, outpacing the FTSE All-Share Index, which gained 11.2% over the same period. The company also raised its dividend for the 59th consecutive year, underscoring its long-standing commitment to rewarding shareholders. Despite uncertainty in global markets, including the impact of U.S. tariff policies and economic headwinds in the UK, the trust delivered standout results, with particularly strong contributions from banking and life insurance holdings. Effective stock selection and disciplined cost control were key drivers of performance, strengthening its position in the UK equity market.

City of London’s valuation remains attractive, supported by consistent financial results, a low price-to-earnings ratio, and a reliable dividend track record. However, technical signals point to potential share price weakness, and the lack of transparency around cash flows introduces some risk. While recent corporate developments reflect management’s confidence, these concerns weigh on the overall outlook.

About City of London Investment Trust PLC

City of London Investment Trust PLC is focused on achieving long-term growth in both income and capital by investing primarily in equities listed on the London Stock Exchange. The trust places particular emphasis on delivering sustainable dividend income to its shareholders.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

GSTechnologies Limited (LSE:GST) has provided an update on its Bitcoin reserve strategy, confirming it currently holds around 8.8 Bitcoin, valued at approximately US$1.02 million. The company intends to gradually expand its holdings in line with its treasury policy, which treats Bitcoin as a long-term digital store of value. This strategy reflects GST’s broader operational focus and long-term financial planning.

While the company has made progress on its digital asset initiatives, it continues to struggle with operational inefficiencies and weak profitability, as shown by poor financial results and negative technical signals. Nonetheless, recent acquisitions and strategic moves suggest potential pathways for future growth, offering a partial counterbalance to its otherwise cautious outlook.

About GSTechnologies Limited

GSTechnologies Limited is a fintech business engaged in the cryptocurrency ecosystem. The company operates the Bake Cryptocurrency Platform and incorporates Bitcoin holdings into its treasury management framework as part of its long-term financial strategy.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

Cobra Resources PLC (LSE:COBR) has released encouraging final results from the re-evaluation of historic drilling samples, confirming the large-scale rare earth element (REE) potential within newly secured tenements at its Boland Project. The findings reveal notable REE mineralization across three key target areas, pointing to a meaningful expansion of the project’s overall scope. With Native Title approval approaching completion, the company is preparing for drill testing aimed at incorporating these results into an initial Mineral Resource Estimate. This progress positions Cobra to bolster its role in supplying critical metals such as terbium and dysprosium, supported by cost-efficient in situ recovery (ISR) mining techniques.

About Cobra Resources PLC

Cobra Resources PLC is a mineral exploration and development company advancing projects in the rare earth element sector. The company is focused on palaeochannel sediment-hosted REE deposits, with an emphasis on environmentally responsible and low-cost in situ recovery (ISR) methods to unlock long-term value.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

Fusion Antibodies plc (LSE:FAB) has reported notable progress on its OptiMAL® program, developed in collaboration with the U.S. National Cancer Institute (NCI). The platform has successfully identified antibodies with strong commercial binding potential, prompting the NCI to explore broader applications. This advancement reinforces Fusion’s position as a specialist in pre-clinical antibody discovery and could accelerate therapeutic and diagnostic initiatives targeting multiple cancer types, creating value for both the company and its stakeholders.

Despite these scientific achievements, Fusion continues to grapple with financial headwinds. The company faces shrinking revenues and heavy losses, while technical indicators suggest ongoing bearish momentum. Valuation challenges also underscore its unprofitable status. Even so, recent capital raises and strategic partnerships offer some encouragement for future growth, though short-term financial stability remains a pressing issue.

About Fusion Antibodies plc

Headquartered in Belfast, Fusion Antibodies plc is a contract research organization focused on antibody engineering for drug development and diagnostic purposes. Founded in 2001 as a spin-out from Queen’s University Belfast, the company provides end-to-end services including antibody creation, development, production, characterization, and optimization. Fusion’s global client base includes eight of the world’s ten largest pharmaceutical companies by revenue.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

M Winkworth Plc (LSE:WINK) has announced a 15% year-on-year increase in network revenues, reaching £32.0 million in the first half of 2025. The performance was fueled by a 27% surge in sales revenues, alongside the opening of three new offices and the refranchising of two locations. The company also raised its dividend, underlining confidence in future growth.

Despite a 19% decline in profit before tax, attributed to exceptional one-off costs, Winkworth reported a doubling of net operating cash and maintained its debt-free balance sheet. Looking ahead, the company expects continued expansion and is on track to surpass its annual goal of opening or reselling at least eight franchises. Market conditions, shaped by government policies and evolving regulations, continue to play a significant role in guiding its strategy.

About M Winkworth Plc

M Winkworth Plc is a prominent London-based franchisor specializing in residential real estate. Operating mainly in the mid to upper-tier sales and lettings markets, the company provides franchise partners with access to its established brand, network, and professional support. Winkworth shares are listed on the AIM market of the London Stock Exchange.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

Moonpig Group plc (LSE:MOON) has kicked off its fiscal year 2026 on a solid note, reporting a 10% year-on-year revenue increase that is in line with company guidance. The online gifting and greeting card platform continues to build momentum through enhanced customer engagement, driven by new personalization tools and a growing subscription base. These initiatives are contributing to higher order values and repeat purchases. The group also plans to roll out additional gifting brands ahead of peak trading seasons, while robust cash generation is expected to support both investment in growth and shareholder returns.

The outlook for Moonpig remains somewhat mixed. Although the company faces financial strain and weak technical indicators, strategic initiatives such as share buybacks provide some support to investor sentiment. Valuation metrics remain subdued, reflecting ongoing profitability challenges.

About Moonpig Group plc

Moonpig Group plc operates leading online platforms for personalized cards and gifts. Its portfolio includes the Moonpig, Red Letter Days, and Buyagift brands in the UK, alongside Greetz in the Netherlands. The company leverages proprietary technology and data insights to enhance personalization, expand gifting options, and deliver next-day services, positioning itself as a key player in the digital gifting sector.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

Quadrise Fuels International (LSE:QED) has successfully completed performance trials of its MSAR® and bioMSAR™ fuels at the Sparkle Power facility in Panama. The testing showed both improved engine efficiency and notable reductions in nitrogen oxide and particulate emissions, reinforcing the potential of these fuels as commercially viable options for energy-intensive industries. These encouraging results support the next steps toward commercial supply agreements and regulatory approvals in Panama, representing a key milestone in Quadrise’s push to strengthen its footprint across Central America.

Despite the progress on the technical front, Quadrise’s overall outlook remains mixed. The company continues to face financial headwinds and valuation challenges, although these are partially offset by favorable technical signals and strategic developments. Its commitment to partnerships and low-emission fuel innovation could provide long-term growth opportunities, but persistent revenue constraints and weak financial performance remain significant hurdles.

About Quadrise Fuels International

Quadrise is a technology-driven company focused on the development and commercialization of MSAR® and bioMSAR™ emulsion fuels. These fuels are designed to lower both energy costs and emissions for industries such as power generation, maritime transport, and oil refining. The company’s strategy centers on delivering practical decarbonization solutions for heavy industry and the global power sector.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

The Avalanche Foundation announced the appointment of Chris Holmes, a Conservative member of the UK House of Lords, to its board of directors.

The appointment, revealed on Tuesday, September 16, 2025, could strengthen ties with lawmakers amid growing global blockchain adoption, enhancing the foundation’s political credibility and influence in international regulatory discussions.

Holmes is recognized for his work in shaping policies on emerging technologies, with a focus on governance, regulation, and innovation. He played a key role in passing the Electronic Commercial Documents Bill, which granted digital, blockchain-enabled documents the same legal status as printed versions, and has advocated for standards on artificial intelligence and labor practices.

In a statement, Nicolas Lemaitre, director of the Avalanche Foundation, said Holmes’ presence will be “essential to uphold standards of openness, accessibility, and trust in the digital economy.”

The appointment comes as regulatory debates around blockchain intensify in major economies. Governments are seeking to establish clear frameworks for cryptocurrencies and decentralized protocols, and having an experienced British legislator on Avalanche’s board exemplifies this effort.

Holmes also emphasized that technological innovation must go hand in hand with proper safeguards. He noted that blockchain has the potential to revolutionize financial systems and data management, provided it is supported by responsible regulation and consistent institutional dialogue.

The Avalanche Foundation, a non-profit organization, supports the Avalanche ecosystem through grants and projects focused on blockchain, artificial intelligence, and Web3.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.