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Fusion Antibodies plc (LSE:FAB) has reported notable progress on its OptiMAL® program, developed in collaboration with the U.S. National Cancer Institute (NCI). The platform has successfully identified antibodies with strong commercial binding potential, prompting the NCI to explore broader applications. This advancement reinforces Fusion’s position as a specialist in pre-clinical antibody discovery and could accelerate therapeutic and diagnostic initiatives targeting multiple cancer types, creating value for both the company and its stakeholders.

Despite these scientific achievements, Fusion continues to grapple with financial headwinds. The company faces shrinking revenues and heavy losses, while technical indicators suggest ongoing bearish momentum. Valuation challenges also underscore its unprofitable status. Even so, recent capital raises and strategic partnerships offer some encouragement for future growth, though short-term financial stability remains a pressing issue.

About Fusion Antibodies plc

Headquartered in Belfast, Fusion Antibodies plc is a contract research organization focused on antibody engineering for drug development and diagnostic purposes. Founded in 2001 as a spin-out from Queen’s University Belfast, the company provides end-to-end services including antibody creation, development, production, characterization, and optimization. Fusion’s global client base includes eight of the world’s ten largest pharmaceutical companies by revenue.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

M Winkworth Plc (LSE:WINK) has announced a 15% year-on-year increase in network revenues, reaching £32.0 million in the first half of 2025. The performance was fueled by a 27% surge in sales revenues, alongside the opening of three new offices and the refranchising of two locations. The company also raised its dividend, underlining confidence in future growth.

Despite a 19% decline in profit before tax, attributed to exceptional one-off costs, Winkworth reported a doubling of net operating cash and maintained its debt-free balance sheet. Looking ahead, the company expects continued expansion and is on track to surpass its annual goal of opening or reselling at least eight franchises. Market conditions, shaped by government policies and evolving regulations, continue to play a significant role in guiding its strategy.

About M Winkworth Plc

M Winkworth Plc is a prominent London-based franchisor specializing in residential real estate. Operating mainly in the mid to upper-tier sales and lettings markets, the company provides franchise partners with access to its established brand, network, and professional support. Winkworth shares are listed on the AIM market of the London Stock Exchange.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

Moonpig Group plc (LSE:MOON) has kicked off its fiscal year 2026 on a solid note, reporting a 10% year-on-year revenue increase that is in line with company guidance. The online gifting and greeting card platform continues to build momentum through enhanced customer engagement, driven by new personalization tools and a growing subscription base. These initiatives are contributing to higher order values and repeat purchases. The group also plans to roll out additional gifting brands ahead of peak trading seasons, while robust cash generation is expected to support both investment in growth and shareholder returns.

The outlook for Moonpig remains somewhat mixed. Although the company faces financial strain and weak technical indicators, strategic initiatives such as share buybacks provide some support to investor sentiment. Valuation metrics remain subdued, reflecting ongoing profitability challenges.

About Moonpig Group plc

Moonpig Group plc operates leading online platforms for personalized cards and gifts. Its portfolio includes the Moonpig, Red Letter Days, and Buyagift brands in the UK, alongside Greetz in the Netherlands. The company leverages proprietary technology and data insights to enhance personalization, expand gifting options, and deliver next-day services, positioning itself as a key player in the digital gifting sector.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

Quadrise Fuels International (LSE:QED) has successfully completed performance trials of its MSAR® and bioMSAR™ fuels at the Sparkle Power facility in Panama. The testing showed both improved engine efficiency and notable reductions in nitrogen oxide and particulate emissions, reinforcing the potential of these fuels as commercially viable options for energy-intensive industries. These encouraging results support the next steps toward commercial supply agreements and regulatory approvals in Panama, representing a key milestone in Quadrise’s push to strengthen its footprint across Central America.

Despite the progress on the technical front, Quadrise’s overall outlook remains mixed. The company continues to face financial headwinds and valuation challenges, although these are partially offset by favorable technical signals and strategic developments. Its commitment to partnerships and low-emission fuel innovation could provide long-term growth opportunities, but persistent revenue constraints and weak financial performance remain significant hurdles.

About Quadrise Fuels International

Quadrise is a technology-driven company focused on the development and commercialization of MSAR® and bioMSAR™ emulsion fuels. These fuels are designed to lower both energy costs and emissions for industries such as power generation, maritime transport, and oil refining. The company’s strategy centers on delivering practical decarbonization solutions for heavy industry and the global power sector.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

The Avalanche Foundation announced the appointment of Chris Holmes, a Conservative member of the UK House of Lords, to its board of directors.

The appointment, revealed on Tuesday, September 16, 2025, could strengthen ties with lawmakers amid growing global blockchain adoption, enhancing the foundation’s political credibility and influence in international regulatory discussions.

Holmes is recognized for his work in shaping policies on emerging technologies, with a focus on governance, regulation, and innovation. He played a key role in passing the Electronic Commercial Documents Bill, which granted digital, blockchain-enabled documents the same legal status as printed versions, and has advocated for standards on artificial intelligence and labor practices.

In a statement, Nicolas Lemaitre, director of the Avalanche Foundation, said Holmes’ presence will be “essential to uphold standards of openness, accessibility, and trust in the digital economy.”

The appointment comes as regulatory debates around blockchain intensify in major economies. Governments are seeking to establish clear frameworks for cryptocurrencies and decentralized protocols, and having an experienced British legislator on Avalanche’s board exemplifies this effort.

Holmes also emphasized that technological innovation must go hand in hand with proper safeguards. He noted that blockchain has the potential to revolutionize financial systems and data management, provided it is supported by responsible regulation and consistent institutional dialogue.

The Avalanche Foundation, a non-profit organization, supports the Avalanche ecosystem through grants and projects focused on blockchain, artificial intelligence, and Web3.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

Openbank, the fully digital bank of the Santander Group (LSE:BNC), began offering cryptocurrency trading to retail clients in Germany on Tuesday, September 16, 2025.

Investors can now buy, sell, and hold Bitcoin (COIN:BTCUSD), Ether (COIN:ETHUSD), Litecoin (COIN:LTCUSD), Polygon (COIN:MATICUSD), and Cardano (COIN:ADAUSD) directly on the same platform used for stocks, ETFs, and funds.

This move is a significant step for Santander in expanding into digital assets, providing clients with an environment regulated under European Union rules following the implementation of MiCA, which ensures greater protection and transparency in crypto financial operations.

According to Coty de Monteverde, Santander Group’s Head of Cryptocurrencies, “the inclusion of these assets on the platform responds to growing customer demand and reinforces the bank’s commitment to offering diversified, agile solutions supported by one of the world’s largest financial groups.”

The bank has set a 1.49% fee per transaction, with a minimum of €1 (US$1.18), and no custody fees, aiming to make the service competitive with independent exchanges while providing the added security of a regulated financial institution.

Openbank plans to expand the list of tradable cryptocurrencies and introduce new features in the coming months, including the ability to convert between different digital assets. The expansion will also include clients in Spain.

Recent reports indicate that Santander has been evaluating the creation or integration of euro- or dollar-pegged stablecoins since May.

With this launch, Openbank joins a growing trend among major European and American banks exploring the crypto sector following regulatory advances. In the United States, new stablecoin legislation and political support have accelerated traditional lenders’ entry into the market.

Openbank continues to expand its digital portfolio. Currently, it offers an automated investment service via Robo Advisor, more than 3,000 stocks, 3,000 funds from 123 managers, over 2,000 ETFs, and a brokerage platform equipped with artificial intelligence for analyzing more than 1,000 global securities.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

U.S. index futures are signaling a mostly flat open on Tuesday, suggesting that stocks may struggle to find direction following a session that ended with modest gains.

Traders appear cautious ahead of the Federal Reserve’s two-day policy meeting, which kicks off today.

While a 25-basis-point rate cut is widely anticipated, market participants will closely examine the Fed’s accompanying statement and updated economic projections for hints about the future path of interest rates.

CME Group’s FedWatch Tool currently shows a 96.0% probability of a quarter-point cut, with only a 4.0% chance of a half-point reduction.

Looking ahead, another 25-basis-point rate reduction is expected at both the October and December meetings, though Fed Chair Jerome Powell is likely to emphasize that future cuts will hinge on incoming economic data.

Futures remained largely unchanged even after the Commerce Department reported that retail sales in August rose far more than economists had forecast.

Retail sales climbed 0.6% in August, matching the upwardly revised gain from July. Analysts had anticipated a smaller increase of 0.2%, compared with the initially reported 0.5% growth for the prior month.

Stocks ended mostly higher on Monday, extending strong gains from the previous week. The Nasdaq and S&P 500 both closed at record levels, with the Nasdaq advancing 207.65 points, or 0.9%, to 22,348.75, and the S&P 500 up 30.99 points, or 0.5%, to 6,615.28. The Dow posted a smaller gain, rising 49.23 points, or 0.1%, to 45,883.45.

Market strength followed encouraging remarks from President Donald Trump regarding U.S.-China trade negotiations.

In a post on Truth Social, Trump said that the talks have “gone VERY WELL!” and added that a “deal was also reached on a ‘certain’ company that young people in our Country very much wanted to save,” likely referencing TikTok.

Trump also noted he plans to speak with Chinese President Xi Jinping on Friday, describing the relationship as “a very strong one.”

Investors remain focused on Wednesday’s Fed announcement, with expectations of at least a 25-basis-point rate cut fueled by recent data showing moderate inflation and a weakening labor market.

On Monday, computer hardware stocks were among the top performers, with the NYSE Arca Computer Hardware Index rising 2.5% to a record closing level. Networking stocks also performed well, reflected by a 2.3% gain in the NYSE Arca Networking Index.

Gold, steel, and software sectors saw notable strength, while airline, oil services, and housing stocks experienced downward pressure.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

European equities traded mostly in the red on Tuesday, while the U.S. dollar slipped to its weakest level in more than two months. Investors are bracing for the Federal Reserve’s two-day policy meeting beginning later today, where markets widely expect a 25 basis point rate cut.

On the data front, the U.K.’s latest labor figures showed the unemployment rate holding steady at 4.7% in the three months to July, according to the Office for National Statistics. Wage growth cooled slightly, with average earnings excluding bonuses rising 4.8% compared to 5.0% in the previous period, in line with forecasts. Payroll employment in August declined by 127,000 year-over-year and was down 8,000 from July, leaving the total at 30.3 million.

Among major European benchmarks, Germany’s DAX dropped 0.7%, London’s FTSE 100 lost 0.3%, and France’s CAC 40 eased 0.1%.

In corporate news, Trustpilot (LSE:TRST) surged in London after reporting stronger revenues and profitability in the first half of 2025, alongside the launch of a new share repurchase plan. Mining giant Anglo American (LSE:AAL) also advanced after striking a definitive agreement with Chile’s Codelco to coordinate activities at Los Bronces and Andina. Hochschild Mining (LSE:HOC) climbed after naming Cassio Diedrich as its new Chief Operating Officer.

On the downside, recruitment firm SThree (LSE:STEM) slumped sharply after warning that its full-year pre-tax profit will fall well short of market expectations.

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.

Cadence Minerals (LSE:KDNC) is positioning itself for a pivotal year as it advances both its flagship Amapá iron ore project and the restart of the Azteca plant — a smaller but strategically important asset.

In a recent interview, CEO Kiran Morzaria explained how Azteca will act as a bridge toward Amapá’s full potential. While the Amapá project boasts a post-tax NPV of $1.97 billion, a 15-year mine life, and a planned production of 5.5 million tonnes of high-grade iron ore annually, Azteca is set to generate near-term cash flow. Backed by a $4.6 million offtake agreement — with Cadence contributing only 10–15% of that amount — the plant offers an efficient way to fund growth without overreliance on placings.

“Azteca is the bridge that gets us there,” Morzaria noted. “It’s a great step forward that allows us to move from Azteca to Amapá.”

Addressing Dilution Concerns

Shareholder worries about dilution remain common across the natural resources sector. Morzaria acknowledged that Cadence has, at times, relied on equity placings, but emphasized the company’s hybrid model: investment gains have historically funded much of its project pipeline.

For Azteca, the majority of financing is provided by the offtake partner rather than shareholders. The Azteca plant is expected to deliver around $32 million of cash flow, which will be reinvested directly into the development of the Amapá project. In addition, Cadence benefits from its 10–15% interest in the offtake structure, which is forecast to generate an internal rate of return approaching 70%. This creates a dual value stream: project reinvestment and exceptional returns to Cadence shareholders.

Cash Flow to Accelerate Development

The real strength of Azteca lies in its ability to produce cash from the very first shipment. Those revenues will flow directly into definitive feasibility studies, permitting, and early works at Amapá, reducing dependence on new equity. If ore volumes and recoveries outperform expectations, Azteca could even support the equity portion of Amapá’s project financing — protecting Cadence’s 36% interest in the world-class iron ore asset.

With Amapá’s scale (NPV $1.97 billion, IRR 56%) and low delivered costs to China, Cadence sees a clear value gap between its market capitalization and its stake in the project. The strategy is straightforward: generate cash, minimize dilution, and prove Amapá’s potential as a top-tier low-cost producer.

Disclaimer:

This content is for informational purposes only and does not constitute financial, investment, or other professional advice. It should not be considered a recommendation to buy or sell any securities or financial instruments. All investments involve risk, including the potential loss of principal. Past performance is not indicative of future results. You should conduct your own research and consult with a qualified financial advisor before making any investment decisions.