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Cizzle Biotechnology Holdings PLC (LSE:CIZ) has raised an additional £250,000 through convertible loan notes from investor Frazer Lang to accelerate the rollout of its CIZ1B biomarker test for the early detection of lung cancer. The new capital will help broaden the test’s reach across North America, the UK, and Europe, while also supporting the company’s ongoing collaborations with healthcare partners such as the NHS to improve early cancer screening and diagnosis.

More about Cizzle Biotechnology Holdings PLC

Cizzle Biotechnology Holdings PLC is a UK-based diagnostics company focused on developing innovative blood tests for the early detection of cancer. Its flagship product, the CIZ1B biomarker test, offers a non-invasive method to identify lung cancer in its initial stages. The company continues to build strategic partnerships to commercialize its proprietary technology and is listed on the London Stock Exchange.

Barclays Research has turned modestly positive on Europe’s luxury goods industry after a better-than-expected third-quarter earnings season suggested that the wave of analyst downgrades may finally be coming to an end.

The bank said that “2026 estimates are in the right place,” underpinned by resilient demand from affluent U.S. consumers and early evidence that “China’s market does not seem to be getting worse.”

As part of its sector review, Barclays upgraded Moncler (BIT:MONC) to “overweight” and downgraded Hermès (EU:RMS) to “equal weight,” while maintaining LVMH (EU:MC) at “equal weight” and Kering (EU:KER) as well as Ferragamo (BIT:SFER) at “underweight.” The brokerage said it continues to hold a “neutral” stance on the overall European Luxury & Specialty Retail space.

Moncler’s upgrade reflected what analysts described as an “attractive risk/reward” setup, with a €61 price target. Barclays noted that the Italian luxury outerwear maker had “benefited less than peers from the sector rebound” and could show sequential growth in Q4 despite challenging comparisons.

Engagement indicators such as Google Trends were said to be “supportive,” while management’s early fourth-quarter comments — “October started well and results are positive” — reinforced optimism.

Moncler’s U.S. expansion remains a key growth driver, with its store base projected to rise 4–5% annually over the next three years. The stock trades at a 2-year forward P/E of 20.7x, representing a 5% discount to its 10-year average.

By contrast, Hermès was cut to “equal weight” with a €2,310 price target, as Barclays cited “fewer short-term catalysts to drive the shares.” The French luxury house, known for its defensive earnings profile, posted single-digit organic growth year to date, a trend Barclays expects to continue through year-end.

Analysts observed that Hermès “still trades on a 2Y fwd PE of 40.0x, which is 1% above its historical average,” calling the stock’s valuation stretched as revenue outperformance narrows. EBIT margins are expected to stay near 40%, as “the operating leverage of the brand is relatively low.”

For LVMH, Barclays kept its €560 target price and Equal Weight rating unchanged. The firm’s Fashion & Leather Goods division is forecast to decline 5% in Q4 amid tougher comparisons, though cost efficiencies may cushion margin pressure. The brokerage also factored in a higher French corporate tax rate, trimming its 2026 EPS forecast by 3%.

Kering’s earnings forecasts for FY25 and FY26 were raised by 18% and 10%, respectively, resulting in a new price target of €245, though Barclays maintained an “underweight” rating. The report noted that the Gucci owner’s 51% rally in recent months “has not been accompanied by EPS upgrades,” and that its 2-year forward P/E of 27.5x now stands almost double its 10-year average.

Barclays also pointed to encouraging signs from China, with LVMH reporting that “Mainland China [was] turning positive in Q3,” while Hermès cited “a quite strong and dynamic business” during Golden Week, and Ferragamo described “an encouraging improvement in China.”

The brokerage added that Richemont (BIT:1CFR) and Burberry (LSE:BRBY) — both due to report mid-November — could benefit from “positive read-across” trends seen among peers.

Despite growing optimism, Barclays warned that the recovery remains fragile, noting that “the sector is not out of the woods yet.” Most brands still posted negative Q3 sales growth, and store traffic challenges continue. While the bank sees potential for improvement in 2026, it cautioned that “a significant EPS momentum inflection is not guaranteed.”

U.S. stock futures pointed to a sharply lower open on Tuesday, suggesting that markets may come under renewed pressure after a mixed session at the start of the week.

A major factor behind the weakness is Palantir Technologies (NASDAQ:PLTR), whose shares tumbled 8.2% in premarket trading, weighing heavily on sentiment across the technology sector.

The sharp decline comes despite the data analytics firm reporting better-than-expected quarterly results and raising its revenue forecast, as investors continue to question the stock’s lofty valuation.

“It speaks to just how supercharged Palantir’s share price has been in 2025 that even a set of numbers as impressive as those it produced for its third quarter were insufficient to sustain the momentum,” said Dan Coatsworth, head of markets at AJ Bell.

He added, “Even in the context of the booming AI sector, the company’s valuation has reached high levels as investors have seized on its perceived close links with the Trump administration and AI-driven revenue growth.”

Elsewhere, Uber Technologies (NYSE:UBER) fell in premarket trading despite delivering third-quarter revenue ahead of Wall Street estimates, while Spotify Technology (NYSE:SPOT) looked set for early gains after the music streaming platform beat forecasts with its latest results.

Broader market sentiment also turned cautious following remarks from Goldman Sachs (NYSE:GS) CEO David Solomon, who warned of potential turbulence in equity markets over the next two years.

“It’s likely there’ll be a 10 to 20 percent drawdown in equity markets sometime in the next 12 to 24 months,” Solomon said at the Global Financial Leaders’ Investment Summit in Hong Kong. “Things run, and then they pull back so people can reassess.”

Monday’s session ended mixed: while the Nasdaq and S&P 500 extended gains, the Dow Jones Industrial Average slipped. The Dow fell 226.19 points, or 0.5%, to 47,336.68, the S&P 500 added 0.2% to 6,851.97, and the Nasdaq climbed 0.5% to 23,834.72.

The Nasdaq’s strength was fueled by Amazon (NASDAQ:AMZN), which rose 4% to a record high following a $38 billion cloud computing partnership with OpenAI, granting access to Amazon Web Services infrastructure for AI workloads.

Nvidia (NASDAQ:NVDA) also advanced 2.2% after Microsoft (NASDAQ:MSFT) confirmed it had received export licenses from the Trump administration to supply Nvidia chips to the United Arab Emirates.

Meanwhile, declines in Merck (NYSE:MRK), down 4.1%, alongside Nike (NYSE:NKE), 3M (NYSE:MMM), and Chevron (NYSE:CVX), weighed on the Dow.

Traders appeared hesitant to make large moves ahead of ADP’s private payroll report, set for release Wednesday, which could provide clues on labor market strength amid uncertainty over interest rates and the ongoing government shutdown.

On the data front, the Institute for Supply Management (ISM) reported that U.S. manufacturing contracted faster than expected in October, with its PMI falling to 48.7 from 49.1 in September. Economists had forecast a slight uptick to 49.5.

Among sectors, oil service stocks gained as crude prices edged higher, sending the Philadelphia Oil Service Index up 2.2%. Retail shares also strengthened thanks to Amazon’s surge, while computer hardware stocks advanced and housing stocks lagged.

European equity markets traded sharply lower on Tuesday as a combination of mixed corporate earnings, disappointing U.S. manufacturing data, and cautious remarks from Federal Reserve officials dampened investor confidence and reduced appetite for riskier assets.

By mid-morning, the FTSE 100 in London was down 0.4%, while France’s CAC 40 dropped 1.0% and Germany’s DAX slid 1.2%.

Among individual movers, Telefónica (BIT:1TEF) saw its shares sink after the Spanish telecom giant announced plans to halve its dividend for 2026 as part of a broader strategic overhaul aimed at reducing debt and boosting efficiency.

Fresenius Medical Care (BIT:1FME) also fell, despite reporting better-than-expected third-quarter results, as the German dialysis group reaffirmed its 2025 guidance, noting that cost-saving initiatives had supported profitability.

Shares of Edenred (EU:EDEN) tumbled after the French employee benefits provider cut its medium-term earnings growth targets, citing macroeconomic headwinds and slower client demand.

In Sweden, Skanska (BIT:1SKAB) edged lower following news that the construction company will invest about SEK 820 million in the fifth phase of its Nowy Rynek office development in Poznań, Poland.

On the upside, Geberit (BIT:1GEBN) gained after the Swiss plumbing materials manufacturer raised its 2025 sales outlook, reflecting improving market demand.

Philips (EU:PHIA) shares also advanced, with the Dutch medical technology group lifting the upper end of its full-year margin forecast after reporting third-quarter revenue in line with market expectations.

Gold prices edged lower in Asian trading on Tuesday, weighed down by a strengthening U.S. dollar and growing uncertainty over the Federal Reserve’s next policy decision following Chair Jerome Powell’s hawkish comments last week.

By 01:58 ET (06:58 GMT), spot gold was down 0.4% at $3,986.10 per ounce, while U.S. gold futures slipped 0.5% to $3,994.30. The metal once again failed to hold above the $4,000 level as the dollar extended its rally, making bullion more expensive for international buyers.

Gold Pressured by Dollar Strength and Fed Ambiguity

The U.S. dollar climbed to a three-month high on Monday against major peers, supported by fading expectations of another interest rate cut this year.

Powell signaled last week that the central bank was not yet committed to further easing, saying a December rate move was “not a foregone conclusion.” As a result, investors have dialed back bets on near-term monetary loosening.

Uncertainty was compounded on Monday when several Fed officials offered differing perspectives on the economic outlook. Some highlighted the ongoing need to guard against inflation, while others warned that the labor market is beginning to cool.

The divergence in views deepened doubts about when the Fed might resume rate cuts, keeping the dollar well-supported.

Gold, which pays no interest, generally loses its appeal in environments of high interest rates or a strong dollar. The prospect of fewer rate cuts and elevated real yields has continued to dampen investor appetite for the precious metal.

Still, analysts noted that downside risks for gold remain limited amid ongoing fragility in U.S.-China trade relations. While recent signs of progress between Washington and Beijing have reassured investors, renewed concerns over restrictions on advanced chip exports have tempered optimism.

Metal Markets Follow Gold Lower

Other precious and industrial metals also retreated as the stronger dollar weighed on sentiment.

Silver futures dropped 1.5% to $47.315 per ounce, while platinum futures fell 1.3% to $1,557.85 per ounce.

On the London Metal Exchange, benchmark copper futures slipped 1.3% to $10,705.20 per ton, and U.S. copper futures mirrored the move, falling 1.3% to $4.99 per pound.

Oil prices retreated on Tuesday as traders interpreted OPEC+’s latest production decision—a pause in output increases during the first quarter—as a potential indication that the market could face oversupply.

By 0700 GMT, Brent crude futures slipped 37 cents, or 0.6%, to $64.52 a barrel, while U.S. West Texas Intermediate (WTI) fell by the same margin to $60.68 a barrel.

The Organization of the Petroleum Exporting Countries and its allies (OPEC+) announced on Sunday that it would implement a modest production hike for December but hold off on further increases in early 2026. The coalition has lifted output targets by roughly 2.9 million barrels per day—equivalent to about 2.7% of global supply—since April but has recently slowed that pace amid growing expectations of a supply surplus.

“(The) market may see this as the first sign of acknowledgement of potential oversupply situation from the OPEC+ front, who have so far remained very bullish on demand trends and ability of market to absorb the extra barrels,” said Suvro Sarkar, energy sector team lead at DBS Bank.

Still, some industry executives are pushing back against talk of an impending glut. The heads of several major European energy firms on Monday argued that global demand remains strong and that production growth is likely to moderate. Meanwhile, U.S. Department of Energy Deputy Secretary James Danly said he does not believe there will be an oil glut in 2026.

Sources within OPEC+ said the decision to maintain steady targets followed lobbying by Russia, which sought a pause as Western sanctions have made it harder for the country to expand exports. Both the U.S. and U.K. imposed new restrictions in October on Rosneft and Lukoil, Russia’s two largest oil producers.

JP Morgan analysts wrote that “our oil strategists maintain their view that while the risk of disruption has increased, U.S. measures, along with complementary actions by the UK and EU, will not prevent Russian oil producers from operating.”

Despite the current slide in prices, independent market analyst Tina Teng said the ongoing sanctions could still provide near-term support to crude markets.

Traders are now awaiting fresh U.S. inventory figures from the American Petroleum Institute (API) later in the day for additional signals. A preliminary Reuters poll indicated that U.S. crude stockpiles likely rose last week.

The U.S. dollar remained steady near its strongest levels in three months on Tuesday, as traders scaled back expectations for further Federal Reserve rate cuts, while the British pound weakened amid renewed political pressure on Finance Minister Rachel Reeves.

At 04:35 ET (09:35 GMT), the Dollar Index, which measures the greenback against a basket of six major currencies, rose 0.1% to 99.770, hovering near its highest point since August.

Dollar Steadies Near Highs

The dollar held firm early Tuesday, as uncertainty grew around the future path of U.S. monetary policy with the ongoing federal shutdown keeping key data releases off the calendar.

The Federal Reserve lowered rates last week, but Chair Jerome Powell signaled it could be the final cut of the year. However, San Francisco Fed President Mary Daly said Monday she would “keep an open mind” regarding the December meeting, while Fed Governor Lisa Cook described the upcoming gathering as “live” for a potential policy move.

“This week is all about reassessing December Fed rate cut expectations,” analysts at ING wrote in a note. “Recent Fed commentary has clearly suggested lower conviction on a preset easing path, which implies some greater data dependency.”

Yet, that data dependency is complicated by the government shutdown, which has halted key economic releases such as the JOLTS job openings report.

“As a result, the few data points we do get – especially tomorrow’s ADP report – can have an outsized impact on markets, while the broader lack of data may lead to more spells of directionless FX trading,” added ING.

Sterling Slips Amid Political Tensions

In Europe, GBP/USD fell 0.4% to 1.3088, as comments from Rachel Reeves, the U.K. finance minister, rattled investors. Reeves said earlier that she would do what is “necessary – not popular – to protect the country against high inflation and high interest rates.”

Reeves is widely expected to introduce tax hikes in the November 26 budget, a move that would contradict her earlier campaign pledge not to raise taxes for “working people.” While politically risky, such action may be required for her to meet fiscal targets — a factor closely watched by bond markets.

Meanwhile, EUR/USD edged 0.1% lower to 1.1509, after briefly touching a three-month low, following weak data showing stagnation in eurozone manufacturing activity during October.

“The slew of post-meeting ECB speakers has added little to the policy narrative. The Governing Council is broadly on the same page with the rates view, and the feeling is that some substantial data surprises are now needed to create new division among policymakers,” said ING.
“If anything, we think the ECB might cut once again, but the risks at the moment aren’t high, and we predict that the easing cycle is over.”

Last week, the European Central Bank kept its key interest rate unchanged at 2% for the third consecutive meeting.

Yen Rebounds After Weakness

In Asia, USD/JPY slipped 0.5% to 153.51, as the yen rebounded from an eight-and-a-half-month low. Japan’s Finance Minister Satsuki Katayama reiterated Tuesday that the government would continue to monitor foreign exchange movements “with a high sense of urgency.”

Although Bank of Japan Governor Kazuo Ueda hinted last week that a rate hike could come as early as December, investors remained skeptical given the central bank’s cautious tone.

Elsewhere, USD/CNY gained 0.1% to 7.1237, while AUD/USD fell 0.3% to 0.6517, after the Reserve Bank of Australia kept interest rates unchanged at 3.60%, as expected.

The Australian central bank noted that inflation remains “materially higher than expected” and warned it would take time to bring price growth back to target — a signal that no immediate policy shift is likely.

Hamak Strategy Limited (LSE:HAMA) has released the voting results from its Extraordinary General Meeting (EGM) held on November 3, 2025, where shareholders approved a resolution authorizing the waiver of pre-emption rights relating to the allotment and issue of new shares.

A total of 155,499,125 votes were cast on the resolution, representing 34.39% of the company’s issued share capital. Of these, 152,985,135 votes (98.38%) were in favor, while 2,513,990 votes (1.62%) opposed the proposal. No votes were withheld.

Last month, the company announced the first drilling results from its joint venture with First Au Limited (ASX:FAU) on its 65% owned Nimba gold project.

Nick Thurlow, Executive Chairman of Hamak Strategy, said:“We are greatly encouraged by the wide intersections of gold mineralisation returned from the first hole assay results, which confirm the depth extensions to the high-grade discovery made by Hamak. We look forward to advancing the drilling programme and reporting further assay results, in partnership with and funded by our JV partners, First Au Limited.”

About Hamak Strategy Limited

Hamak Strategy Limited is a UK-listed company engaged in gold exploration across Africa. The firm is also developing a compliant Bitcoin and cryptocurrency treasury management strategy as part of its broader diversification and capital optimization initiatives. The company was formerly known as Hamak Gold Ltd but changed its name in September 2025.

U.S. stock futures edged lower on Tuesday as investors weighed comments from Federal Reserve officials, fresh corporate earnings, and an increasingly uncertain economic outlook. The session followed a mixed start to November trading, with tech names under renewed pressure after Palantir’s post-earnings decline.

Futures Slide

By 02:58 ET, Dow futures were down 313 points (0.7%), S&P 500 futures lost 61 points (0.9%), and Nasdaq 100 futures dropped 311 points (1.2%).

Wall Street ended Monday mixed — the Dow Jones Industrial Average slipped, while the S&P 500 and Nasdaq Composite posted modest gains.

Investors continued to assess recent dealmaking activity. Kimberly-Clark (NASDAQ:KMB) announced plans to acquire Kenvue (NYSE:KVUE) — maker of Band-Aid — in a $40 billion deal, though analysts flagged potential legal risks. Meanwhile, OpenAI revealed a $38 billion agreement with Amazon (NASDAQ:AMZN) to expand its cloud capabilities, marking the ChatGPT creator’s first major move since its corporate restructuring last week.

Fed Comments Add to Market Uncertainty

Divisions among Fed officials have become more visible. In her first remarks since President Donald Trump’s failed attempt to remove her, Fed Governor Lisa Cook said there was ongoing debate over the central bank’s dual mandate and noted that December’s meeting is a “live” one, indicating uncertainty about the next rate decision.

Similarly, San Francisco Fed President Mary Daly described last week’s rate cut as a form of “insurance” against further labor market weakness but emphasized she would keep an “open mind” ahead of next month’s meeting.

Palantir Shares Fall Despite Strong Quarter

Palantir (NASDAQ:PLTR) shares dropped in extended trading, despite the company reporting record third-quarter revenue and profit that exceeded expectations. The firm, known for its defense and data analytics software, posted net profit of $475.6 million on $1.18 billion in sales, both above forecasts.

CEO Alex Karp said the company is “now producing more profit in a single quarter than it did in revenue not long ago.” Palantir also guided for stronger-than-expected fourth-quarter sales, boosted by rising AI demand.

Even so, the stock’s 175% surge this year has raised concerns about lofty valuations in AI-related equities, dragging down other major tech names in Europe during early trading.

AMD Set to Report Results

Advanced Micro Devices (NASDAQ:AMD) will report its latest quarterly results after the bell, joining the growing list of AI chipmakers releasing earnings amid a wave of new deals in the sector.

According to Reuters, the U.S. Department of Energy has launched a $1 billion partnership with AMD to build two supercomputers for advanced research in medicine and national security. The company also recently announced a multi-year supply agreement with OpenAI, which could generate billions in annual revenue and grant the AI firm a 10% stake in AMD.

Executives at AMD — a top rival to Nvidia — called the partnership “certainly transformative” for both companies and the wider AI industry. AMD shares have climbed over 115% this year, reflecting investor enthusiasm for the sector.

BP Tops Profit Expectations

BP (NYSE:BP) reported third-quarter adjusted net income of $2.21 billion, above forecasts of $2.02 billion, as stronger refining margins helped offset lower oil prices. The company maintained its $750 million share buyback and expects to complete $5 billion in asset disposals this year.

“We’ve delivered another quarter of good performance across the business with operations continuing to run well,” said CEO Murray Auchincloss. “We are looking to accelerate delivery of our plans, including undertaking a thorough review of our portfolio to drive simplification and targeting further improvements in cost performance and efficiency,” he added.

BP’s net debt stood at $26.05 billion, slightly higher than last year’s $24.27 billion, as the company continues its strategic reset to streamline operations and improve returns.

Norway’s Wealth Fund Rejects Musk’s $1 Trillion Tesla Pay Deal

The Norwegian sovereign wealth fund, the world’s largest, said it will vote against Tesla’s (NASDAQ:TSLA) proposed $1 trillion compensation package for CEO Elon Musk, citing governance concerns.

The fund stated that while it “appreciate[s] the significant value created under Mr. Musk’s visionary role,” it is “concerned about the total size of the award, dilution, and lack of mitigation of key person risk.”

Holding a 1.2% stake in Tesla, the fund ranks as the company’s sixth-largest institutional investor. Other major shareholders — including BlackRock, Vanguard, and State Street — have not yet disclosed their voting intentions.

Tesla will hold its annual shareholder meeting later this week, where the results of the vote will be announced. Under the proposed plan, Musk would receive an additional 12% equity stake if he succeeds in driving Tesla’s valuation to $8.5 trillion within the next decade — a goal tied to the company’s pivot toward AI and robotics.

European stocks slipped on Tuesday as investors took profits following a string of record highs and amid lingering uncertainty over the region’s economic outlook. The pullback also came as markets digested a wave of fresh corporate earnings.

As of 08:05 GMT, Germany’s DAX fell 1.4%, France’s CAC 40 lost 1.4%, and the U.K.’s FTSE 100 traded 0.7% lower.

Investors Lock In Gains

Global equities have rallied to record levels this year, from New York to Tokyo, and European indices have followed suit. The DAX is up more than 20% year-to-date, the FTSE 100 has gained over 18%, while France’s CAC 40, weighed down by political uncertainty, has risen by just under 10%.

However, sentiment remains cautious as growth momentum across the eurozone remains fragile. Many investors are now cashing in on recent gains amid signs of slowing economic activity.

Recent data showed that eurozone manufacturing activity stalled in October, with the final PMI reading at 50.0, precisely on the threshold separating expansion from contraction. The picture varies across member states: Greece (53.5) and Spain (52.1) showed strong improvements, while Germany (49.6) and France (48.8) continued to contract.

Meanwhile, expectations for further monetary easing by the European Central Bank are fading. The ECB held interest rates steady last week for the third consecutive meeting, and markets largely expect no change in December’s policy decision.

BP Leads Earnings Headlines

Earnings season continued in Europe with several major companies reporting on Tuesday. BP (LSE:BP.) posted a third-quarter underlying replacement cost profit of $2.21 billion, beating forecasts, and kept its $750 million share buyback unchanged. The company also reaffirmed its plan for $5 billion in asset disposals this year.

Associated British Foods (LSE:ABF), owner of Primark, Twinings, and Ovaltine, reported lower annual profit and announced a strategic review that could result in separating its retail and food divisions.

In Germany, Hugo Boss (TG:BOSS) said sales and operating profit for the year would come in at the lower end of its guidance, after reporting weaker-than-expected third-quarter results.

Philips (EU:PHIA) raised the upper end of its full-year margin forecast, reporting strong third-quarter earnings driven by rising orders and expanded profitability.

Domino’s Pizza (LSE:DOM) delivered a rise in like-for-like sales in the third quarter, supported by price adjustments, new menu items, and loyalty initiatives that helped sustain demand in a challenging market.

Elsewhere, Norway’s Aker ASA (TG:FKM) posted a solid third quarter, with growth in net asset value and strong investment activity in artificial intelligence and real estate.

Oil Prices Ease on Supply Concerns

Oil prices slipped as traders reacted to the latest OPEC+ meeting, which resulted in a modest production increase for December and a pause in early 2026. Brent crude dropped 1% to $64.27 a barrel, while WTI fell 1% to $60.46. Investors now await U.S. inventory data from the American Petroleum Institute later in the day for further direction.