Author: Fiona Craig

  • AstraZeneca and HUTCHMED report Phase III results for Tagrisso-Orpathys combination

    AstraZeneca and HUTCHMED report Phase III results for Tagrisso-Orpathys combination

    AstraZeneca (LSE:AZN) and HUTCHMED reported results from the SANOVO Phase III trial in China evaluating Tagrisso in combination with Orpathys as a first-line treatment for certain patients with non-small cell lung cancer.

    The trial showed a statistically significant and clinically meaningful improvement in progression-free survival for the combination compared with Tagrisso alone in treatment-naïve patients with EGFR-mutated, MET-overexpressing non-small cell lung cancer.

    The companies also reported trends in overall survival and said the safety profile of the all-oral combination was consistent with previously reported data.

    SANOVO evaluates combination in first-line setting

    The SANOVO study assessed the Tagrisso-Orpathys combination in patients who had not previously received treatment for EGFR-mutated, MET-overexpressing non-small cell lung cancer.

    The results extend the clinical evaluation of the combination into the first-line setting following the Phase III SAFFRON and SACHI trials, which studied the regimen in previously treated patients.

    The companies did not provide information in the supplied material regarding regulatory submissions or approvals resulting from the SANOVO findings.

    AstraZeneca develops targeted lung cancer therapies

    AstraZeneca is a global biopharmaceutical company with operations across oncology and other disease areas, including the development of treatments for lung cancer.

    Its lung cancer portfolio includes targeted therapies such as Tagrisso and Orpathys, alongside immunotherapies and other agents being developed for different stages of non-small cell lung cancer.

  • Chariot signs framework agreement for additional Angola oil exposure

    Chariot signs framework agreement for additional Angola oil exposure

    Chariot Limited (LSE:CHAR) has signed a framework agreement with Etu Energias and BW Energy to provide operational and technical support in connection with Etu Energias’ acquisition of additional interests in offshore Angola Blocks 14 and 14K.

    Under the arrangement, Chariot will receive economic exposure equivalent to approximately 4,000 barrels of oil per day. The company has indicated a net present value of more than $100 million for this exposure based on an oil price of $60 per barrel.

    The transaction increases Chariot’s economic exposure to oil production in Angola and extends its existing partnership with Etu Energias and Shell’s trading arm.

    Blocks 14 and 14K produce about 42,000 barrels per day

    Blocks 14 and 14K are producing offshore oil assets in Angola. Together, the blocks currently produce approximately 42,000 barrels of oil per day and have estimated remaining reserves of 93 million barrels.

    The licences extend into the 2030s, according to the information provided.

    BW Energy will be involved in the partnership alongside Etu Energias and Chariot. The arrangement also provides exposure to potential future developments associated with the blocks using existing infrastructure.

    Chariot increases focus on producing upstream assets

    Chariot said the transaction is consistent with its strategy of increasing its exposure to producing assets and associated revenues, with the company expecting the interests to generate cash flows over the medium term.

    Chariot Limited is an Africa-focused energy group operating across upstream oil and gas and renewable power.

    Its upstream business has assets in Angola and Morocco and is focused on securing production. The company’s renewable activities include power projects in South Africa and green hydrogen development in Mauritania. Chariot plans to monetise its renewable interests to support further expansion of its upstream operations.

  • East Star Resources agrees Rulikha copper joint venture as drilling receives approval

    East Star Resources agrees Rulikha copper joint venture as drilling receives approval

    East Star Resources (LSE:EST) has signed a binding heads of agreement with Nova to establish a joint venture covering the Rulikha copper project in East Kazakhstan.

    Under the proposed structure, Nova will be able to earn an interest of up to 75% or 65% in the project through a series of staged milestones, while East Star will retain an interest of at least 25%.

    Local mine developer Orion has been appointed as operator of the project. The arrangement is structured so that Nova and Orion will fund the work required to advance Rulikha, allowing East Star to retain an interest without providing further funding for those activities.

    Nova and Orion to fund development work

    Nova and Orion will fund resource drilling, feasibility studies, permitting and construction at Rulikha at no additional cost to East Star.

    The two companies previously developed the Karshyga and Kamkor copper mines, which subsequently entered profitable operations.

    East Star said the joint venture structure will allow it to direct its own capital towards exploration activities and its other ventures, including its joint venture with Endeavour Mining.

    Rulikha drilling programme planned for Q3 and Q4 2026

    East Star has also received drilling approval for the principal Rulikha licence area. A drilling programme is planned for the third and fourth quarters of 2026.

    The programme will form part of the work to advance the project through resource definition and subsequent development stages under the joint venture arrangement.

    East Star Resources is a London-listed gold and copper exploration and development company focused on Kazakhstan. Its activities target volcanogenic massive sulphide and polymetallic deposits.

    The company’s portfolio of copper assets in East Kazakhstan also includes the Verkhuba-Xinhai joint venture, with East Star using partnerships with local operators to advance projects through exploration and development.

  • Europa Oil & Gas extends EG-08 farm-out deadline to 30 September

    Europa Oil & Gas extends EG-08 farm-out deadline to 30 September

    Europa Oil & Gas (LSE:EOG) has extended the longstop date for completing the farm-out of a 40% interest in the EG-08 production sharing contract offshore Equatorial Guinea to Fuhai.

    The deadline has been moved to 30 September 2026 by mutual agreement as Fuhai continues to seek Chinese outbound investment approval required for the transaction.

    According to Europa, the approval process has taken longer than expected following the introduction of new regulations in China.

    Chinese outbound investment approval remains pending

    The farm-out has already received approval from Equatorial Guinea’s Ministry for Mining and Hydrocarbons.

    In China, Fuhai’s Outbound Direct Investment application remains under consideration by the Beijing Municipal Development and Reform Commission. Europa said the commission has indicated that it expects approval to be granted in the near term.

    Completion of the transaction remains subject to the outstanding Chinese approval process.

    Barracuda-1 well targeted for early 2027

    Europa reiterated its intention to drill the Barracuda-1 exploration well on the EG-08 block at the earliest opportunity, with drilling currently targeted for early 2027.

    Europa Oil & Gas (Holdings) plc is an AIM-quoted exploration, development and production company with oil and gas assets in West Africa, the UK and Ireland.

    The group holds a 42.9% equity interest in Antler Global Limited, which operates the EG-08 production sharing contract offshore Equatorial Guinea alongside national oil company GEPetrol and farm-in partner Fuhai.

  • Finseta expects 2026 revenue of about £11 million following first-half decline

    Finseta expects 2026 revenue of about £11 million following first-half decline

    Finseta plc (LSE:FIN) said first-half 2026 revenue is expected to be approximately £5.4 million, compared with £5.9 million in the same period a year earlier, as macroeconomic conditions affected customer demand and extended sales cycles.

    Active customer numbers increased to 1,389 during the period. The company continued to shift its business towards business-to-business customers, with corporate accounts representing 74% of revenue.

    Finseta expects its gross margin for the first half to be approximately 66%. However, the change in customer mix, planned strategic investment, disruption related to conflict in Dubai and the withdrawal of a currency corridor contributed to an adjusted EBITDA loss for the period.

    The company now expects full-year 2026 revenue of approximately £11 million.

    Dubai revenue increases as regional disruption affects activity

    Finseta reported that revenue from its Dubai operations increased 243% year on year. However, the company said regional conflict constrained activity during the period, resulting in the operation making a lower contribution than internally forecast.

    Management said it is maintaining cost discipline as the group continues its strategic transition.

    Finseta expects the proportion of revenue generated from corporate customers to increase further during the second half, which management expects to result in an additional improvement in gross margin.

    The company is also seeking to replace the provider of a withdrawn currency corridor and expects to restore the affected capabilities through a new provider during the fourth quarter.

    Finseta continues transition towards corporate customers

    Finseta said its strategic transition is taking longer than originally planned as it increases its focus on corporate customers.

    The London-headquartered company provides foreign exchange and payment services, including multi-currency accounts and cross-border payment solutions for businesses and individuals.

    Finseta operates a proprietary technology platform and supports payments in more than 150 currencies across over 165 countries. The company operates under regulatory oversight in the UK, Canada and Dubai.

  • Oxford Metrics acquires Captive Devices to expand Vicon facial capture capabilities

    Oxford Metrics acquires Captive Devices to expand Vicon facial capture capabilities

    Oxford Metrics (LSE:OMG) has acquired Manchester-based Captive Devices, a developer of professional head-mounted camera systems and software for markerless facial performance capture.

    The transaction is valued at up to £750,000 and will be funded through a combination of existing resources and new shares. Oxford Metrics will acquire the entire share capital of Captive Devices without taking on additional debt.

    As part of the transaction, the founding team of Captive Devices will join Oxford Metrics’ Vicon business.

    Acquisition adds facial capture technology to Vicon platform

    Captive Devices develops technology used for facial performance capture in visual effects, gaming and virtual production. Its systems include integration with Unreal Engine.

    The acquisition expands Vicon’s motion capture offering beyond body tracking by adding integrated facial capture capabilities alongside its existing marker-based, markerless and hybrid technologies.

    Oxford Metrics plans to make Captive Devices’ technology available through Vicon’s international sales channels and existing customer relationships. The company aims to broaden the market for its products, increase sales of facial capture systems and continue developing its end-to-end capture platform.

    Oxford Metrics serves customers in more than 70 countries

    Oxford Metrics provides smart sensing and measurement technologies across the life sciences, entertainment, engineering and manufacturing markets.

    Through its Vicon motion capture division and Industrial Vision and Metrology Systems business, the group supplies motion measurement and machine vision solutions to thousands of customers across more than 70 countries.

  • Croma Security Solutions acquires London locksmith William Channon in £1 million deal

    Croma Security Solutions acquires London locksmith William Channon in £1 million deal

    Croma Security Solutions Group (LSE:CSSG) has acquired A. Butler & Sons, which trades as William Channon, in a cash transaction estimated at £1 million and funded from the group’s existing resources.

    The acquisition gives Croma a permanent presence in London and adds William Channon’s commercial locksmith and access control operations to its existing security services network.

    William Channon recorded £1.1 million turnover in 2025

    Based in Holborn and founded in 1917, William Channon serves commercial customers including museums and universities.

    The business generated unaudited turnover of £1.1 million in 2025 and recorded a small pre-tax loss. Its net assets were broadly in line with the estimated £1 million purchase price.

    William Channon’s managing director will remain involved for a short transition period on a consultancy basis.

    Croma plans to restructure the acquired business and said it sees opportunities for cost synergies and for offering additional security services to William Channon’s existing and larger corporate customers.

    Acquisition expands Croma’s London operations

    The transaction forms part of Croma’s acquisition strategy following the sale of its man guarding business in 2023. The company has been acquiring and integrating locksmith businesses as it develops a national network of security centres.

    The William Channon acquisition provides Croma with a base in the London market while adding an established commercial customer portfolio to the group.

    Croma Security Solutions Group provides locksmith, fire and security services to domestic and commercial customers. The AIM-listed company is headquartered in Southampton and operates security centres serving sectors including health, education, leisure, entertainment and utilities.

  • Bitcoin could climb to $300,000 by 2029, Bernstein analyst says

    Bitcoin could climb to $300,000 by 2029, Bernstein analyst says

    Bitcoin (COIN:BTCUSD) could reach $300,000 by the end of 2029 as mounting sovereign debt and the prospect of currency debasement increase the appeal of scarce assets, according to Bernstein analyst Gautam Chhugani.

    The forecast assumes Bitcoin broadly maintains the four-year market cycle that has characterised its historical price movements. Before reaching the projected 2029 peak, Bernstein expects the cryptocurrency to recover to a fresh record of $150,000 by mid-2027.

    “Following our price-to-marginal cost framework, we would expect the next market peak to be $300K by CY2029E and the market recovering to new all-time high of $150,000 by mid-2027E,” Chhugani wrote in a note to clients.

    Higher borrowing costs shape Bernstein’s Bitcoin outlook

    A central part of Bernstein’s argument is that the prolonged period of falling interest rates that characterised the previous 40 years has ended.

    With sovereign debt already at unprecedented levels, governments now face the prospect of substantially higher debt-servicing costs. Bernstein believes rising yields can create a feedback loop in which larger interest expenses widen budget deficits, leading governments to issue additional debt.

    “Faced with the choice between fiscal stress and currency debasement, we believe the policymakers will ultimately favor the latter, as it is politically less disruptive,” the firm said.

    If policymakers ultimately tolerate greater currency debasement to manage fiscal pressures, Bernstein believes investors could increasingly seek assets with structurally limited supply.

    Bernstein sees Bitcoin leading the debasement trade

    Bitcoin stands out as the leading hard asset within this thesis, according to the firm.

    Bernstein estimates that approximately 60% of Bitcoin is held by investors who have demonstrated limited sensitivity to price fluctuations, maintaining their positions even through drawdowns exceeding 50%.

    That relatively stable ownership base is being accompanied by expanding access for institutional and retail investors, potentially providing additional sources of demand during future market cycles.

    Bernstein believes this combination of limited supply, established long-term holders and broader investor access supports its longer-term price projections.

    Strategy target lowered despite Outperform rating

    Alongside its Bitcoin forecast, Bernstein lowered its price target for Strategy (NASDAQ: MSTR) to $350 from $450.

    The firm nevertheless maintained its Outperform rating, noting that Strategy remains the largest corporate Bitcoin holder globally.

    The company owns approximately 4% of the world’s Bitcoin supply, maintaining significant exposure to future movements in the cryptocurrency’s price.

  • Permian natural gas enters new infrastructure growth phase, Citi says

    Permian natural gas enters new infrastructure growth phase, Citi says

    The Permian Basin is entering a multi-year period of natural gas infrastructure expansion that could address longstanding transportation constraints while supporting continued production growth, according to Citi.

    Unlike previous investment cycles, the bank believes the latest wave of infrastructure spending is being underpinned by structural demand growth. Expanding U.S. LNG exports and rising power requirements from AI data centers are encouraging companies to commit to new capacity earlier and at greater scale.

    Citi expects these trends to eventually make the Permian the largest natural gas-producing basin in the U.S., complementing its existing position as the country’s leading source of crude oil.

    Pipeline expansion could improve Waha pricing

    Four recently announced infrastructure projects represent an inflection point for the Permian gas market, according to Citi.

    Combined with capacity additions already underway and the expected acceleration in U.S. LNG exports, the new projects could help narrow Waha Hub price differentials and improve the economics of oil-focused drilling through 2030.

    Permian natural gas production expanded substantially over recent years, rising from 17.2 billion cubic feet per day in 2021 to an estimated 27.6 bcf/d in 2025.

    Pipeline capacity did not increase quickly enough to absorb that additional output, contributing to pricing disruptions at Waha during 2024 and 2025. The imbalance became even more pronounced during the first half of 2026.

    AI electricity demand adds another source of gas consumption

    Growing LNG exports are expected to provide an increasingly important source of demand for U.S. natural gas through the remainder of the decade.

    Domestic electricity consumption could also play a larger role. The U.S. Energy Information Administration’s August 2026 Short-Term Energy Outlook forecasts that natural gas consumption by the power sector will reach a record 46.1 bcf/d during summer 2027.

    That would be approximately 6% above consumption levels during the summers of both 2025 and 2026.

    The trend is particularly significant in Texas. Natural gas-fired generation within ERCOT is projected to increase by roughly 22% between summer 2025 and summer 2027, with data center-related electricity demand accounting for much of the expected growth.

    Texas regulators recently paused new interconnection approvals, however, leading the EIA to lower its 2027 projection.

    Producers look to secure long-term takeaway capacity

    Citi expects exploration and production companies operating in the Permian to take a more active role in securing access to pipeline infrastructure.

    Strategies could include taking equity stakes in pipelines and entering long-term agreements that guarantee transportation capacity.

    The bank pointed to Devon Energy and Diamondback Energy (NASDAQ:FANG) through Solitude, along with Exxon Mobil’s relationship with Targa Resources, as examples of producers seeking greater control over their gas transportation requirements.

    Such arrangements could become increasingly important as associated gas production rises alongside continued oil drilling.

    Storage data suggests tighter gas market

    Gas-focused exploration and production stocks have risen around 4.4% over the past month, even as forward natural gas strip prices have remained broadly unchanged and prompt-month prices continue to trade at depressed levels.

    Citi’s storage model provides another indication that underlying supply-and-demand conditions could be somewhat tighter than headline pricing suggests.

    Actual inventory additions have consistently undershot the bank’s forecasts over the past month, with the difference averaging approximately 1.6 bcf/d.

  • Global oil supply faces unprecedented conflict exposure six months into Iran war

    Global oil supply faces unprecedented conflict exposure six months into Iran war

    More than 43% of global oil supply originates from countries affected by conflict in 2026, according to Reuters calculations, illustrating the unusually high geopolitical exposure currently facing the energy market.

    The situation comes six months after U.S. and Israeli attacks on Iran set off what has developed into the largest recorded oil supply crisis, with uncertainty remaining over how long the disruption will continue.

    At the same time, the Russia-Ukraine war has reduced both production and refining activity, with neighbouring Kazakhstan also experiencing cuts during the year.

    Persistent instability in Libya and U.S. restrictions on Venezuelan oil exports introduced earlier in 2026 have placed additional pressure on available global supplies.

    Around 45 million barrels per day exposed to conflict

    Countries affected by these conflicts collectively produced approximately 45 million barrels per day in 2025, according to Reuters calculations based on International Energy Agency data.

    That volume represents more than 43% of worldwide supply, highlighting the extent to which current oil production is concentrated in regions facing geopolitical disruption.

    The situation has increased the importance of U.S. production to the global market. However, American oil supplies have not been entirely immune from disruption, with severe weather occasionally affecting output.

    The overall impact has also been moderated by the fact that the various supply interruptions experienced this year have not all occurred simultaneously.

    Gulf oil flows remain under pressure

    In the Gulf, producers have taken steps to maintain exports despite the disruption. Saudi Arabia has redirected oil towards the Red Sea, while other exporters have continued moving supplies through the Strait of Hormuz.

    Even with those measures, analysts estimate that the current disruption to Gulf oil flows amounts to roughly 5 million to 7 million barrels per day.

    The threat to major shipping routes remains significant. Attacks in the Red Sea and close to Egypt’s Suez Canal during July demonstrated how further escalation could affect important corridors for international oil and fuel shipments.

    The Gulf and Ukraine conflicts have also had a significant effect downstream, reducing global refining capacity by approximately one-tenth.

    Ukraine has repeatedly targeted Russia’s refining infrastructure, including facilities as far away as Omsk, around 2,700 kilometres (1,680 miles) from Ukrainian-held territory.

    Refining disruptions tighten fuel markets

    Russia is now dealing with fuel shortages at home and has banned gasoline and diesel exports, adding further tightness to international refined-product markets.

    Higher fuel prices have increasingly contributed to inflationary pressures, pushing up borrowing costs and helping drive U.S. government debt to a record $40 trillion.

    U.S. diesel prices have reached record highs despite domestic refiners operating at maximum capacity.

    The International Energy Agency has attempted to soften the impact of the supply crisis through record releases from emergency oil stockpiles.

    Most of those releases have now been completed. With global inventories continuing to decline, the market has less of an emergency cushion available if geopolitical disruptions intensify further.