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  • Unicycive Therapeutics Announces FDA Acceptance of Oxylanthanum Carbonate NDA Resubmission, PDUFA Date of March 25, 2027

    Unicycive Therapeutics Announces FDA Acceptance of Oxylanthanum Carbonate NDA Resubmission, PDUFA Date of March 25, 2027

    Resubmission includes Chemistry, Manufacturing, and Controls (CMC) data from new drug product (DP) manufacturing vendor

    Mountain View, California – Unicycive Therapeutics, Inc. (“Unicycive” or the “Company”) (NASDAQ:UNCY), a clinical-stage biotechnology company developing therapies for patients with kidney disease, today announced that the U.S. Food and Drug Administration (FDA) has accepted the resubmission of its New Drug Application (NDA) for oxylanthanum carbonate (OLC), the Company’s investigational oral phosphate binder for the treatment of hyperphosphatemia in patients with chronic kidney disease (CKD) on dialysis. The NDA was resubmitted following a Complete Response Letter (CRL) received in June 2026. The FDA has deemed the OLC resubmission a Class II with a six-month review period from the resubmission date, and set a Prescription Drug User Fee Act (PDUFA) target action date of March 25, 2027.

    Unicycive Therapeutics, Inc. is a B2i Digital Featured Company. See the company’s in-depth profile at: https://b2idigital.com/unicycive-therapeutics

    “We are pleased that the FDA has accepted the resubmission of our NDA for OLC and assigned a PDUFA date,” said Shalabh Gupta, M.D., Chief Executive Officer of Unicycive. “This resubmission includes CMC data from a new third-party drug product manufacturing vendor. The new vendor’s facility was last inspected by the FDA in March 2024 and received ‘No Action Indicated’ status. We hope to continue working with the FDA toward potential approval of this important medication to patients with CKD on dialysis who need additional treatment options for managing hyperphosphatemia.”

    The Company does not know whether the FDA will decide to conduct a pre-approval inspection of the new third-party DP vendor. Additionally, if the original third-party manufacturing vendor is inspected in the near term and finds that its facility complies with current Good Manufacturing Practice (cGMP), the Company plans to seek FDA alignment on a shorter approval timeline.

    The Company resubmitted the NDA following the second CRL, which cited deficiencies previously identified at the original third-party manufacturer of the drug product, which the FDA had not been able to re-inspect during the prior submission review.

    The timing and outcome of any FDA inspection of the original third-party vendor will be determined solely by the FDA.

    The NDA is supported by data from three clinical studies (a Phase 1 study in healthy volunteers, a bioequivalence study in healthy volunteers, and a tolerability study of OLC in CKD patients on dialysis), multiple preclinical studies, as well as CMC data. The FDA did not raise any concerns regarding OLC’s preclinical or clinical data, including safety data, included in the original NDA submission.

    About Oxylanthanum Carbonate

    OLC is an investigational oral phosphate binder that leverages proprietary nanoparticle technology to deliver high phosphate binding potency, reducing the number and size of pills that patients must take to treat hyperphosphatemia in patients with chronic kidney disease (CKD) on dialysis. Its potential best-in-class profile may have meaningful patient adherence benefits over currently available treatment options as it requires a lower pill burden. Unicycive is seeking FDA approval of OLC via the 505(b)(2) regulatory pathway. OLC is protected by a strong global patent portfolio including issued patents on composition of matter with exclusivity until 2031, and with the potential for patent term extension until 2035.

    About Hyperphosphatemia

    Hyperphosphatemia is a serious medical condition that occurs in nearly all patients with End Stage Renal Disease (ESRD). Annually there are over 450,000 individuals in the U.S. that require medication to control their phosphate levels.1 Uncontrolled hyperphosphatemia is strongly associated with increased death and hospitalization for CKD patients on dialysis. Treatment of hyperphosphatemia is aimed at lowering serum phosphate levels via two means: (1) restricting dietary phosphorus intake; and (2) using, on a daily basis, and with each meal, oral phosphate binding drugs that facilitate fecal elimination of dietary phosphate rather than its absorption from the gastrointestinal tract into the bloodstream.

    1Flythe JE. Dialysis-Past, Present, and Future: A Kidney360 Perspectives Series. Kidney360. 2023 May 1;4(5):567-568. doi: 10.34067/KID.0000000000000145.

    About Unicycive Therapeutics

    Unicycive Therapeutics is a biotechnology company developing novel treatments for kidney diseases. Unicycive’s lead investigational treatment is oxylanthanum carbonate, a novel phosphate binding agent for the treatment of hyperphosphatemia in patients with chronic kidney disease who are on dialysis. Unicycive’s second investigational treatment UNI-494 is intended for the treatment of conditions related to acute kidney injury. It has been granted orphan drug designation (ODD) by the FDA for the prevention of Delayed Graft Function (DGF) in kidney transplant patients and has completed a Phase 1 dose-ranging safety study in healthy volunteers. For more information, please visit Unicycive.com.

    Forward-looking statements

    Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. These statements may be identified using words such as “anticipate,” “believe,” “forecast,” “estimated” and “intend” or other similar terms or expressions that concern Unicycive’s expectations, strategy, plans or intentions. These forward-looking statements are based on Unicycive’s current expectations and actual results could differ materially. There are several factors that could cause actual events to differ materially from those indicated by such forward-looking statements. These factors include, but are not limited to, clinical trials involve a lengthy and expensive process with an uncertain outcome, and results of earlier studies and trials may not be predictive of future trial results; Unicycive’s clinical trials may be suspended or discontinued due to unexpected side effects or other safety risks that could preclude approval of our product candidates; Unicycive’s dependence on third parties for manufacturing; the possibility that FDA may require inspection of any vendor prior to approval, which could delay or prevent approval of its NDA; the risk that the inspection of the original or new third-party manufacturing vendor may not occur within a timeframe that benefits its regulatory timeline, or may result in adverse findings; risks related to business interruptions, which could seriously harm its financial condition and increase its costs and expenses; dependence on key personnel; substantial competition; uncertainties of patent protection and litigation; dependence upon third parties; market acceptance of its products; and risks related to failure to obtain FDA clearances or approvals and noncompliance with FDA regulations. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties related to market conditions and other factors described more fully in the section entitled ‘Risk Factors’ in Unicycive’s Annual Report on Form 10-K for the year ended December 31, 2025, and other periodic reports filed with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Unicycive specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

    Investor Contacts:

    Kevin Gardner
    LifeSci Advisors
    [email protected]

    Media Contact:
    Unicycive Therapeutics
    [email protected] 

    Additional Contact:

    David Shapiro
    B2i Digital, Inc.
    +1 212-579-4844
    [email protected]

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    SOURCE: Unicycive Therapeutics, Inc.

  • US Stock Futures Point Higher as Investors Assess Earnings and Await Major Technology Results: Dow Jones, S&P, Nasdaq, Wall Street

    US Stock Futures Point Higher as Investors Assess Earnings and Await Major Technology Results: Dow Jones, S&P, Nasdaq, Wall Street

    US equity futures indicated a positive start to Wednesday’s trading session, with investors responding to corporate earnings announcements and preparing for further financial updates from some of the country’s largest technology companies.

    The anticipated advance followed two sessions of gains in parts of the US market, although Tuesday’s trading ended with a mixed performance among the major indices.

    Technology-related stocks were expected to attract attention at the opening bell following substantial pre-market movements in several companies.

    SpaceX (NASDAQ:SPCX) gained 8.8% before the market opened after reporting third-quarter earnings above analysts’ expectations and a substantial year-on-year increase in revenue.

    The company also attracted attention after Elon Musk confirmed that SpaceX and Tesla (NASDAQ:TSLA) had formed independent special committees to consider a possible merger.

    The announcement indicated that the companies were examining the potential transaction, although no agreement or final decision had been disclosed.

    Super Micro Computer (NASDAQ:SMCI) recorded an even larger pre-market increase of 12.2% after raising its revenue forecast for the first quarter of its fiscal year.

    The server manufacturer’s updated outlook contributed to movements in shares associated with data centre infrastructure and artificial intelligence computing.

    Elsewhere, Netflix (NASDAQ:NFLX) declined 6.8% in pre-market dealings despite reporting third-quarter earnings above market estimates.

    The decline followed revenue guidance that fell short of analysts’ expectations, illustrating the importance investors were placing on companies’ forward-looking forecasts.

    Telecommunications group AT&T (NYSE:T) also traded lower, falling 5% even though its latest quarterly results exceeded expectations for both revenue and earnings.

    Attention was expected to shift towards Tesla, Meta Platforms (NASDAQ:META) and IBM (NYSE:IBM), with all three companies scheduled to release their financial results after Wednesday’s closing bell.

    The forthcoming announcements could provide further information about corporate spending, technology demand and business conditions across several industries.

    Tuesday’s session had produced gains for the Dow Jones Industrial Average and S&P 500, while the Nasdaq Composite ended marginally lower.

    The Dow climbed 529.85 points, or 1%, to 52,495.88, reaching its highest closing level in more than a month.

    The S&P 500 increased by 21.84 points, equivalent to 0.3%, to finish at 7,712.57. The Nasdaq Composite edged down 6.07 points, or less than 0.1%, to 26,424.82.

    Shares in 3M (NYSE:MMM) contributed to the Dow’s advance, rising 6% after the industrial group announced third-quarter earnings above forecasts and increased its full-year profit outlook.

    Amgen (NASDAQ:AMGN), Merck (NYSE:MRK) and UnitedHealth (NYSE:UNH) were among the other Dow constituents recording gains.

    Energy markets also influenced Tuesday’s trading.

    US crude oil futures reversed an earlier increase and moved substantially lower following a media report suggesting that diplomatic negotiations could help reduce tensions between Washington and Tehran.

    Al-Araby Al-Jadeed reported that negotiators representing Qatar and Pakistan had proposed a compromise intended to end the conflict between the United States and Iran.

    Citing an unnamed source, the publication indicated that an announcement concerning a possible halt to the escalation could emerge during the week.

    The report remained unconfirmed by both the US and Iranian governments.

    The decline in crude oil prices coincided with improved demand for equities, although uncertainty surrounding the conflict remained a consideration for investors.

    Several market sectors also recorded notable advances during Tuesday’s session.

    Pharmaceutical shares gained, lifting the NYSE Arca Pharmaceutical Index by 2.8% to its highest closing level in two months.

    Housing-related stocks also moved higher, with the Philadelphia Housing Sector Index advancing 2.6%.

    Biotechnology, healthcare and airline companies participated in the broader gains, alongside most other major industry groups.

    Wednesday’s trading is expected to be influenced by further corporate earnings announcements, with the reports from Tesla, Meta Platforms and IBM among the principal events on the calendar.

    Investors will also continue monitoring developments in energy markets and the US-Iran conflict as they assess the outlook for equities.

  • European Shares Advance as UK Inflation Accelerates and Corporate Earnings Drive Trading: DAX, CAC, FTSE100

    European Shares Advance as UK Inflation Accelerates and Corporate Earnings Drive Trading: DAX, CAC, FTSE100

    European stock markets traded mostly higher on Wednesday as investors assessed UK inflation figures, corporate earnings announcements and developments in energy markets.

    Gains were moderated by higher oil prices following comments from Iranian President Masoud Pezeshkian, who said the United States must end its threats and pressure, reduce pressure in the region and remove economic sanctions before negotiations could take place.

    Economic data from the UK showed that annual consumer price inflation increased to 3.5% in September from 3.1% in August, according to the Office for National Statistics (ONS). The reading exceeded economists’ forecast of 3.4% and marked the highest rate since October of the previous year.

    Core inflation, which excludes energy, food, alcohol and tobacco, rose to 2.8% from 2.6% in August. Separate government figures indicated that the UK’s budget deficit widened by more than economists had anticipated in September.

    Among the main European indices, Germany’s DAX gained 0.9%, while France’s CAC 40 advanced 0.7%. The UK’s FTSE 100 recorded a smaller increase of 0.1%.

    Corporate announcements contributed to movements in individual shares across the region.

    German sportswear manufacturer Adidas (TG:ADS) traded higher after increasing its full-year profit guidance.

    Shares in property company Aroundtown (TG:AT1) also advanced following an announcement that its subsidiary, Grand City Properties SA, had acquired a 20.04% interest in German residential landlord LEG Immobilien SE (TG:LEG). LEG Immobilien shares rose 3.3%.

    Recruitment group Randstad (EU:RAND) gained after reporting third-quarter results above market expectations and indicating an improvement in trading trends.

    Medical technology company Getinge (TG:GTN) advanced after its third-quarter profit exceeded analysts’ forecasts.

    Spanish electricity group Iberdrola (TG:IBE1) moved higher after raising its annual profit target for the second time this year.

    Eurofins Scientific (EU:ERF), which provides laboratory testing and analytical services, also recorded gains after reaffirming its financial objectives for 2027.

    Elsewhere, Aberdeen (LSE:ABDN) shares declined in London despite the investment manager reporting that assets under management and administration had increased by 4% at the end of September compared with the end of 2025.

    French payments company Edenred (EU:EDEN) fell after reducing its earnings before interest, tax, depreciation and amortisation (EBITDA) guidance for 2026.

    Swedish industrial group SKF also traded lower despite reporting improved third-quarter profit and margins.

    The trading session reflected a combination of UK economic developments, company-specific earnings announcements and uncertainty surrounding energy prices, with investors continuing to assess the implications for European businesses and financial markets.

  • Brent Approaches $110 as Middle East Risks and US Stockpile Decline Influence Oil Markets

    Brent Approaches $110 as Middle East Risks and US Stockpile Decline Influence Oil Markets

    Crude oil prices increased on Wednesday as investors monitored the security situation in the Middle East and a larger-than-expected reduction in US oil inventories. Concerns about shipping through the Strait of Hormuz remained a focus amid uncertainty surrounding the conflict involving Iran.

    Brent crude futures rose 1.1% to $109.96 per barrel at 05:28 ET (09:28 GMT), while West Texas Intermediate (WTI) futures gained 1.2% to $99.01 per barrel.

    The gains followed renewed reports about the possibility of further military operations against Iran, alongside continued concerns about the movement of oil shipments through one of the world’s principal energy transportation routes.

    Reports of Possible Israeli Offensive Add to Supply Uncertainty

    Israeli Prime Minister Benjamin Netanyahu is seeking to restart large-scale military strikes against Iran, according to a report published by the Financial Times on Wednesday.

    The newspaper said Netanyahu had instructed the Israeli military to prepare another offensive earlier in October. Those plans were not implemented after US President Donald Trump called for attacks on Iran to be suspended until after the November US midterm elections, according to the report.

    The prospect of renewed hostilities has kept attention on the Strait of Hormuz, where maritime traffic has faced restrictions since the conflict began in February.

    Any further disruption to shipping could affect the movement of crude oil and other energy products from the Middle East.

    Oil prices had briefly fallen on Tuesday after unconfirmed reports suggested that Qatar and Pakistan had proposed restarting negotiations to end the conflict.

    Brent declined from approximately $112 to $106 per barrel following those reports, before recovering as doubts emerged about the prospects for an agreement.

    The subsequent increase followed reports of remarks attributed to Iran’s president suggesting that the United States might carry out further attacks if negotiations resumed.

    Shipping Security Remains a Concern in the Strait of Hormuz

    Iranian media reported on Tuesday that another supertanker had caught fire in the Strait of Hormuz, citing the Islamic Revolutionary Guard Corps.

    The report followed other incidents affecting commercial shipping in the area during recent weeks.

    Fighting involving Saudi Arabia and Yemen’s Iran-backed Houthi movement has also contributed to uncertainty over regional energy transportation.

    David Morrison, senior market analyst at Trade Nation, highlighted the relationship between prolonged hostilities and the availability of emergency oil reserves.

    “Oil prices have stayed relatively subdued given the supply risks. But as hostilities drag on, and as it’s no longer possible to draw on significant strategic reserves, there’s a danger that crude prices become unanchored,” Morrison said.

    Despite the conflict, Gulf oil exports have exceeded pre-war levels, according to shipping data from Kpler cited by The Wall Street Journal.

    The report indicated that US efforts to provide security for vessels crossing the Strait of Hormuz have helped maintain shipments.

    However, the newspaper also identified uncertainty about whether current export volumes can be sustained and the financial costs associated with protecting commercial shipping.

    API Reports Larger-Than-Expected US Crude Inventory Draw

    Figures released by the American Petroleum Institute showed that US crude inventories fell by 4.93 million barrels in the week ended 16 October.

    Analysts had expected a reduction of approximately 1.3 million barrels, making the reported decline considerably larger than forecast.

    The figures followed two weeks of substantial inventory withdrawals, during which oil production along the US Gulf Coast was affected by Hurricane Isaias.

    The latest report provided an additional indication of reduced commercial crude supplies in the United States.

    Official government inventory data are scheduled for release later on Wednesday, with market expectations pointing to a decline of around 300,000 barrels.

    Although API figures are closely followed by oil traders, they do not necessarily match the official inventory report because the two datasets use different reporting sources and methodologies.

    The inventory reductions have occurred while the US Strategic Petroleum Reserve remains at its lowest level in 44 years, following months of emergency withdrawals intended to address disruptions in global energy supplies.

    The reduced availability of strategic reserves has added another consideration for market participants assessing the ability of oil supplies to respond to further disruptions.

    Oil markets therefore entered Wednesday’s session with attention divided between geopolitical developments, maritime security in the Middle East and changes in US crude stockpiles.

  • Gold Prices Slip Below $4,120 as Iran War Uncertainty and Fed Rate Expectations Persist

    Gold Prices Slip Below $4,120 as Iran War Uncertainty and Fed Rate Expectations Persist

    Gold prices moved lower on Wednesday as investors monitored developments surrounding the conflict between the United States and Iran, fluctuations in energy markets and expectations for Federal Reserve monetary policy.

    Spot gold declined 0.2% to $4,117.31 per ounce at 02:36 ET (06:36 GMT), while US gold futures fell by the same percentage to $4,134.92 per ounce.

    The decline extended across other precious metals. Silver lost 1.2% to $57.2955 per ounce, platinum decreased 1.8% to $1,627.45, and spot palladium fell 1.6% to $1,088.40.

    The US Dollar Index rose 0.1% to 101.80, providing an additional factor for investors assessing dollar-denominated commodities.

    Bullion has declined more than 1% since the start of the week and remains approximately one-fifth below its level when the US-Iran conflict began in late February.

    The conflict has affected energy supplies and contributed to higher oil prices, raising questions about the outlook for inflation and interest rates.

    Gold does not provide interest income, meaning higher yields on bonds and other interest-bearing assets can increase the opportunity cost of holding the metal.

    Oil Market Volatility Adds to Uncertainty Over Inflation

    Oil prices were broadly stable on Wednesday after declining from a five-month high in the previous session.

    The earlier retreat followed reports suggesting that diplomatic efforts could lead to an agreement to end the conflict involving Iran.

    Those reports were subsequently challenged by a diplomat who rejected suggestions that an agreement was close.

    Gold initially gained as oil prices declined following the reports of possible negotiations, before reversing its advance when crude prices recovered.

    The US dollar and government bond yields also moved lower during the period of fluctuating energy prices.

    Market participants continued to assess the possible effects of developments in the Middle East on energy availability and inflation.

    Higher energy prices can contribute to inflationary pressures, potentially influencing the interest rate decisions of central banks.

    For gold investors, the relationship between inflation expectations and monetary policy remains relevant because changes in interest rates can affect the relative attractiveness of non-yielding assets.

    US Housing Figures Indicate Slower Activity

    Recent US economic data provided additional information about conditions in the domestic economy ahead of the Federal Reserve’s next policy meeting.

    September housing starts declined, while pending home sales fell to a record low, indicating reduced activity in the residential property market.

    Longer-dated US Treasury securities advanced as oil prices retreated and investors considered the economic data.

    The movements in Treasury prices were accompanied by lower bond yields, which can affect demand for precious metals.

    The housing figures added to the economic indicators being monitored as investors evaluated the potential direction of US monetary policy.

    Federal Reserve Expected to Hold Rates in October

    The Federal Reserve is scheduled to hold its next monetary policy meeting on 27–28 October, with market participants largely expecting no change to the benchmark interest rate.

    Comments from Fed Chair Kevin Warsh on Friday did not materially alter those expectations.

    Market pricing indicated a probability of less than 17% that policymakers would raise interest rates by 25 basis points at the October meeting.

    Nevertheless, inflation remains above the Fed’s 2% target, and traders were assigning an approximately 85% probability to another rate increase before the end of 2026.

    Warsh’s remarks preceded the central bank’s communications blackout period, which begins on Saturday and restricts public commentary from Federal Reserve officials ahead of the policy decision.

    With limited additional guidance expected from policymakers before the meeting, investors are focusing on economic releases, Treasury yields and developments in energy markets.

    Gold’s decline on Wednesday came as uncertainty surrounding the Iran conflict and the direction of US interest rates continued to influence precious metals trading.

  • Wall Street Futures Gain as Musk Discusses SpaceX-Tesla Merger and Investors Await Meta Results: Dow Jones, S&P, Nasdaq

    Wall Street Futures Gain as Musk Discusses SpaceX-Tesla Merger and Investors Await Meta Results: Dow Jones, S&P, Nasdaq

    US equity futures edged higher on Wednesday as markets prepared for quarterly results from major technology companies and assessed developments involving SpaceX, Tesla, Anthropic and Nvidia. Investors also monitored oil prices and geopolitical developments in the Middle East, alongside concerns about financing for artificial intelligence infrastructure.

    S&P 500 futures increased 0.2%, or 13 points, by 03:01 ET (07:01 GMT), while Nasdaq 100 futures advanced 0.5%, equivalent to 148 points. Dow Jones futures showed little movement.

    The gains followed a mixed session on Wall Street on Tuesday, when the S&P 500 and Dow Jones Industrial Average finished higher but the Nasdaq Composite closed marginally lower.

    Oil prices remained volatile following unconfirmed reports that Qatar and Pakistan had presented a proposal to restart negotiations aimed at resolving the conflict involving Iran.

    Brent crude initially declined from approximately $112 to $106 per barrel before recovering. The movement coincided with an improvement in equity market sentiment following recent concerns about AI-related investment and corporate borrowing costs.

    “The relief from energy that played out late in the European session meant equities rallied as investors overcame some of their earlier AI jitters,” Deutsche Bank analysts wrote.

    Brent later traded around $110 per barrel after reports emerged of comments attributed to Iran’s president concerning the possibility of renewed US military action.

    Technology shares remained relatively subdued. A semiconductor sector index fell 0.29%, although it recovered from steeper losses earlier in the session. CoreWeave (NASDAQ:CRWV), which provides cloud infrastructure for AI applications, also recovered.

    Musk Confirms Review of Potential SpaceX-Tesla Combination

    Elon Musk said committees representing SpaceX (NASDAQ:SPCX) and Tesla (NASDAQ:TSLA) have begun examining a possible merger.

    The announcement came during an investor call following SpaceX’s third-quarter earnings report.

    Musk said the committees had not agreed on “the terms of any transaction” and cautioned that there was “no guarantee” a deal would be completed.

    He nevertheless said there was “a lot of merit” to the proposed combination. Musk is chief executive of both companies but does not sit on either committee.

    Shares of SpaceX and Tesla rose during extended trading following the remarks.

    A merger would combine SpaceX’s commercial launch and satellite operations with Tesla’s electric vehicle manufacturing and technology businesses. The companies have not announced a proposed transaction structure, valuation or completion timetable.

    SpaceX reported quarterly revenue of $14.6 billion, more than 160% above the comparable period last year and ahead of market expectations.

    Profit totalled $4.4 billion, while capital expenditure reached $19.6 billion.

    The figures were included in SpaceX’s second quarterly financial report since its stock market debut earlier this year.

    Tesla is due to release its own quarterly earnings after Wednesday’s closing bell.

    Anthropic Financial Disclosures Highlight Customer Concentration and Computing Requirements

    Anthropic (NASDAQ:ANTP), the developer of Claude AI, reported first-half revenue of $16.3 billion, according to media coverage of disclosures associated with a possible initial public offering.

    The reported figures showed that two customers accounted for approximately 20% of the company’s revenue during the six-month period.

    Anthropic warned that a “significant portion” of its revenue would continue to come from a “limited” number of customers for the foreseeable future.

    The disclosures also addressed the company’s ability to obtain sufficient computing capacity to support its AI models as demand and development requirements increase.

    Anthropic reported a net loss exceeding $80 billion, compared with a loss of $13 billion in the previous year. The increase was largely associated with an accounting adjustment.

    Other identified risks included potential legal exposure connected with the use of AI systems, including cybersecurity-related incidents.

    Media reports indicated that Anthropic could seek a valuation of approximately $2 trillion in a future IPO. The company has not confirmed a final valuation or listing date.

    Meta Quarterly Results in Focus as AI Capital Spending Expands

    Meta Platforms (NASDAQ:META) will report quarterly earnings after the US market closes on Wednesday, providing investors with an update on its financial performance and investment plans.

    The company has continued developing its AI products, including the Muse model introduced in September.

    According to the reported information, Muse attracted millions of downloads following its launch. Its applications include travel planning assistance and tools designed for small businesses.

    Meta has also released an open-weight version of Muse Spark intended for coding-related tasks.

    The company’s results arrive as major technology groups expand spending on AI computing infrastructure, including advanced chips and data centres.

    These investments have become a central issue for equity investors, particularly as companies increase their capital commitments while the timing of future returns remains uncertain.

    Meta’s earnings release and management commentary are expected to provide updated guidance on capital expenditure and the commercial development of its AI services.

    Nvidia Linked to Further Funding for Australian AI Cloud Company

    Nvidia (NASDAQ:NVDA) is reportedly considering an additional investment worth hundreds of millions of dollars in Australian AI infrastructure provider Firmus Grid.

    The Information reported that discussions were taking place after Firmus abandoned its planned initial public offering in Australia.

    Nvidia already holds an ownership interest in Firmus and has made investments in other AI cloud infrastructure companies.

    Firmus cancelled its proposed listing earlier this month, citing financial market volatility and concluding that proceeding would not serve shareholders’ interests under the prevailing conditions.

    The company had previously considered an IPO at a valuation exceeding $30 billion, which would have ranked among Australia’s largest stock market offerings.

    No agreement or final investment amount has been announced.

    The developments involving SpaceX, Tesla, Anthropic, Meta and Nvidia place corporate financing and AI investment plans among the principal company-specific themes for Wednesday’s US trading session, alongside quarterly earnings and movements in energy markets.

  • European Gas Prices Rise Over 3% Amid Persian Gulf Supply Disruptions and UK Inflation Increase

    European Gas Prices Rise Over 3% Amid Persian Gulf Supply Disruptions and UK Inflation Increase

    European wholesale natural gas prices advanced more than 3% on Wednesday as disruptions to energy shipments through the Persian Gulf and lower regional storage levels continued to affect supply conditions ahead of the winter heating season.

    The benchmark Dutch TTF front-month contract rose 3.1% to €87.95 per megawatt-hour (MWh), while UK National Balancing Point (NBP) natural gas futures increased 3.2% to 216.57 pence per therm. Both contracts were trading near their highest levels since late 2022.

    The price increases coincided with the publication of UK inflation figures showing that annual consumer price inflation reached 3.5% in September, up from 3.1% in August and above market expectations.

    Higher energy import costs remain a consideration for the British economy, which relies on pipeline gas and liquefied natural gas (LNG) shipments to meet domestic heating and electricity generation requirements.

    The UK’s relatively limited long-term gas storage capacity also leaves the country dependent on continuing imports during periods of increased demand.

    European gas benchmarks have recorded substantial gains since the beginning of 2026. Dutch TTF prices were approximately 210% higher year to date, while the UK NBP benchmark had risen around 196%.

    Supply disruptions in the Persian Gulf have contributed to the increase in prices. Maritime strikes and restrictions affecting transit through the Strait of Hormuz have reduced the availability of LNG shipments from the Middle East.

    According to the reported figures, Middle Eastern LNG deliveries to Europe were nearly 80% below their level a year earlier.

    The reduction in available supplies has increased competition between European and Asian importers for LNG cargoes from the Atlantic basin, particularly those not already committed under long-term contracts.

    European gas storage inventories have also become an important factor as the winter heating season approaches.

    Underground storage facilities across Europe were reported to be approximately 74.6% full, their lowest seasonal level since 2009.

    The lower storage level reduces the volume of gas available to meet additional demand or compensate for interruptions to imported supplies.

    The combination of restricted LNG shipments, competition for alternative cargoes and reduced storage inventories has contributed to higher wholesale gas prices across Europe.

    The latest UK inflation figures have added to the broader economic context, although the immediate movement in gas futures primarily coincided with developments affecting supply availability and expectations for winter demand.

  • European Shares Little Changed as Investors Await US Technology Earnings: DAX, CAC, FTSE100

    European Shares Little Changed as Investors Await US Technology Earnings: DAX, CAC, FTSE100

    European stock markets traded close to unchanged levels on Wednesday, following two sessions of volatility, as investors assessed corporate earnings, political developments in France and forthcoming financial results from major US technology companies.

    The pan-European STOXX 600 index was broadly flat at 638 points, after fluctuating during the previous session. The benchmark had fallen by as much as 1% before recovering most of its losses to close near unchanged levels.

    In London, the FTSE 100 declined 0.2% after UK data showed that annual consumer price inflation had accelerated to 3.5% in September, exceeding market expectations.

    France’s CAC 40 also fell 0.2%, while Germany’s DAX remained broadly unchanged.

    Among individual stocks, EssilorLuxottica (EU:EL) gained 11.2% after the eyewear manufacturer, which owns the Ray-Ban brand, reported third-quarter revenue above analysts’ consensus estimates.

    The company’s results provided support to consumer discretionary shares, while broader European market performance remained mixed.

    Political and social developments in France continued to influence market sentiment. Civil unrest and the introduction of mandatory nighttime curfews in Paris and Nice added to concerns surrounding the country’s political and fiscal situation.

    French government bond yields and credit default swap spreads increased amid these developments, reflecting changes in the pricing of sovereign credit risk.

    Investors were also assessing expectations for the European third-quarter earnings season.

    According to Reuters, earnings among STOXX 600 companies are forecast to increase 20.7% year on year, compared with growth of 24.0% recorded in the second quarter.

    More than half of the index’s total market capitalisation is represented by companies scheduled to publish quarterly financial updates over the next two weeks.

    These announcements will provide additional information on corporate profitability and business conditions across European sectors.

    European Technology Shares Advance Ahead of Meta and Tesla Results

    European semiconductor and technology stocks recorded modest gains as investors awaited quarterly financial reports from major US technology companies.

    BE Semiconductor (EU:BESI), ASM International (EU:ASM), ASML (EU:ASML) and STMicroelectronics (BIT:STMMI) each advanced by more than 1% during the session.

    The increases followed declines across global technology shares during the previous week, when investors reassessed valuations and financing requirements associated with artificial intelligence infrastructure.

    Attention turned to quarterly results from Meta Platforms (NASDAQ:META) and Tesla (NASDAQ:TSLA), scheduled for release later on Wednesday.

    Investors were particularly focused on company spending plans, including capital expenditure associated with artificial intelligence and related computing infrastructure.

    Recent market discussions have centred on the scale of investment required to develop AI capabilities, the use of corporate debt financing and the timing of potential financial returns from these projects.

    Management commentary accompanying the forthcoming US earnings announcements is expected to provide further information on investment plans and spending expectations.

    European equities therefore remained broadly stable during Wednesday’s session, with individual company results supporting selected stocks while political developments, inflation data and upcoming US technology earnings continued to influence trading.

  • Entain Shares Rise 4.5% as BetMGM Reports Higher Revenue and EBITDA

    Entain Shares Rise 4.5% as BetMGM Reports Higher Revenue and EBITDA

    Entain (LSE:ENT) shares rose 4.5% to 454.5p on Wednesday, following recent financial updates from the gambling group and its BetMGM joint venture, alongside analyst assessments of the company’s outlook.

    BetMGM, the 50-50 joint venture between Entain and MGM Resorts International, reported third-quarter 2026 net revenue of $710 million, representing a 7% increase compared with the same period last year.

    Adjusted EBITDA rose 112% to $86 million, while the joint venture distributed $68 million in cash to its two parent companies during the quarter.

    The results followed Entain’s third-quarter trading update on 15 October, which showed growth in its UK and Ireland online operations.

    Online net gaming revenue (NGR) in the region increased 14%, exceeding market expectations. Within this segment, gaming revenue rose 17%, while online volumes increased 15%.

    Entain also reported double-digit growth in New Zealand, Spain and Canada, although its Brazilian operations continued to face difficulties associated with the country’s nationwide restrictions on online gambling.

    The company maintained its financial guidance for the full year 2026, forecasting online net gaming revenue growth of between 4% and 6% at constant exchange rates.

    Entain also reiterated its expectation that underlying EBITDA would be at the lower end of its previously announced range of £910 million to £960 million.

    The group’s latest trading figures and the performance of BetMGM have been accompanied by updated analyst recommendations.

    Goldman Sachs maintained its Buy rating on Entain but reduced its price target to £8.00 from £10.40.

    Morgan Stanley also retained its Overweight recommendation while lowering its target price to £10.00 from £10.50.

    Both investment banks therefore maintained their existing ratings despite revising their valuations of the company’s shares.

    The broader UK equity market was also supported by developments in US corporate earnings and bond yields, although investors remained focused on forthcoming UK inflation and government borrowing figures.

    During Wednesday’s session, Entain shares traded close to an intraday high of 458.3p.

    At 454.5p, the stock remained below its 52-week high of 826.6p.

    The share price increase followed the publication of BetMGM’s quarterly results, which showed higher revenue, adjusted EBITDA and cash distributions, together with Entain’s previously reported growth in its UK and Ireland online business.

    The company continues to target full-year online revenue growth while maintaining its existing underlying EBITDA guidance. The relative contribution of these developments to Wednesday’s share price movement cannot be determined from the available information.

  • Carrefour Shares Fall Over 11% as Retailer Lowers 2026 Financial Guidance

    Carrefour Shares Fall Over 11% as Retailer Lowers 2026 Financial Guidance

    Carrefour (EU:CA) shares declined more than 11% on Wednesday after the French retail group reduced its full-year financial forecasts, citing deteriorating social and security conditions in France that have affected store operations and consumer spending.

    The company reported third-quarter like-for-like sales growth of 2.3%, compared with an increase of 2.1% during the first half of 2026.

    Despite the quarterly sales increase, Carrefour revised its expectations for operating profitability, earnings per share and cash generation for the full year.

    The retailer now forecasts growth in its recurring operating income margin of between zero and 15 basis points, compared with its previous target of 25 basis points.

    Carrefour also reduced its adjusted earnings per share guidance, now expecting broadly stable earnings or slight growth rather than the high single-digit increase previously anticipated.

    The company revised its net free cash flow outlook from slight growth to a slight decline for 2026.

    Management attributed the changes to recent developments in France, which have disrupted operations at a number of urban stores and created uncertainty surrounding consumer spending.

    In its domestic market, Carrefour recorded third-quarter like-for-like sales growth of 1.2%, with increases across its different store formats.

    The company said pricing investments made earlier in the year contributed to the French sales performance.

    In Spain, like-for-like sales rose 2.1%, supported by higher sales volumes.

    Brazil reported like-for-like growth of 1.4%, with the Atacadão retail format contributing to the increase.

    Alexandre Bompard, Chairman and Chief Executive Officer of Carrefour, commented on the group’s quarterly trading performance and the situation affecting its French operations.

    “Carrefour recorded +2.3% like-for-like sales growth in the third quarter, in line with the first half of the year, driven by food sales and the positive contribution from our core markets,” Bompard said.

    “The events that have taken place in France over the last few days have affected a significant number of our stores in urban areas and have placed our teams and partners in particularly difficult situations.”

    The company indicated that recent events had affected a significant number of stores in French urban areas, complicating the operating environment ahead of the year-end retail period.

    Carrefour also reported an 18% increase in e-commerce sales during the third quarter, reflecting growth in its online retail activities.

    The group continued expanding its convenience store network, opening 89 new locations across France and Spain during the period.

    The quarterly results therefore showed increased like-for-like sales across Carrefour’s principal markets, alongside growth in online sales and further store openings.

    However, the retailer’s revised financial guidance reflects its assessment of the potential effects of current operating conditions in France on profitability and cash flow during the remainder of 2026.

    The reduction in its full-year targets coincided with a decline of more than 11% in Carrefour’s share price during Wednesday’s trading session.