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  • Thalia Therapeutics Completes Initial Synthesis for THAT-002 Cardiovascular Programme

    Thalia Therapeutics Completes Initial Synthesis for THAT-002 Cardiovascular Programme

    Thalia Therapeutics (LSE:THAT) has completed the initial chemistry synthesis of THAT-002, its bispecific siRNA gene-silencing programme targeting PCSK9 and lipoprotein(a).

    The programme is being developed with WuXi AppTec and forms part of Thalia’s RNA therapeutics pipeline for cardiovascular disease.

    Thalia said the synthesis work was completed on time and within budget.

    In Vitro Studies to Begin

    Completion of the synthesis stage allows Thalia to begin in vitro studies of THAT-002. The company also plans to start in vivo work later in the fourth quarter.

    Data generated from these studies are expected to inform subsequent preclinical development and potential IND-enabling studies.

    THAT-002 is being developed to simultaneously target PCSK9 and lipoprotein(a), or Lp(a), using a single bispecific siRNA therapy. Thalia is investigating the approach as a potential treatment targeting factors associated with cardiovascular disease risk.

    Further development of the programme remains dependent on the results of preclinical studies and subsequent development stages.

    About Thalia Therapeutics

    Thalia Therapeutics plc is a biotechnology company developing RNA-based therapeutics and delivery technologies for oncology and cardiovascular disease.

    Its pipeline includes miRisten (THAT-001) for Acute Myeloid Leukaemia, THAT-002 for atherosclerotic cardiovascular disease and the Nuvec delivery platform (THAT-003).

    The company’s development approach focuses on RNA technologies designed to silence or modify therapeutic gene targets.

  • Upland Resources Publishes Interim Results for First Half of 2026

    Upland Resources Publishes Interim Results for First Half of 2026

    Upland Resources Limited (LSE:UPL) has published its interim financial results for the six months ended 30 June 2026.

    The interim report has been made available on the company’s website and provides an update covering the group’s financial and operational position during the first half of the year.

    The publication forms part of Upland’s disclosure requirements under UK Market Abuse Regulation.

    Upland Continues Oil and Gas Activities

    Upland is pursuing oil and gas exploration and development opportunities, with activities focused on Southeast Asia and the United States.

    The company said its strategy involves identifying energy assets with resource potential and participating in upstream projects through investments and partnerships.

    No securities are being offered in connection with the publication of the interim financial results.

    About Upland Resources

    Upland Resources Limited is an oil and gas company with shares traded on the LSE and OTCQB markets.

    The company pursues exploration and development opportunities across Southeast Asia and the United States, with its activities including investments, partnerships and participation in upstream oil and gas projects.

  • Schroders Capital Global Innovation Trust Completes Tender Offer

    Schroders Capital Global Innovation Trust Completes Tender Offer

    Schroders Capital Global Innovation Trust plc (LSE:INOV) has completed its tender offer after shareholders tendered more shares than were available for repurchase.

    The company said a total of 457,274,764 ordinary shares were tendered under the offer, with 124,276,792 shares ultimately repurchased.

    Following completion of the tender offer, Schroders Capital Global Innovation Trust has 511,085,133 ordinary shares in issue.

    Excess Tenders Scaled Back

    The trust said shareholders’ basic entitlements under the tender offer were satisfied in full.

    As the number of shares submitted exceeded the amount available for repurchase, tenders above shareholders’ basic entitlements were scaled back.

    Completion of the transaction has also changed the company’s total voting rights. Shareholders can use the revised number of shares in issue when determining whether they are required to notify changes in their holdings under applicable UK disclosure and transparency requirements.

    About Schroders Capital Global Innovation Trust

    Schroders Capital Global Innovation Trust plc is a London-listed investment trust managed by Schroder Investment Management.

    The trust invests in companies operating across a range of innovation-focused sectors globally, with an investment objective centred on generating long-term capital growth for shareholders through a diversified portfolio.

  • Gemfields Expects Wider Interim Loss Following Montepuez Impairment

    Gemfields Expects Wider Interim Loss Following Montepuez Impairment

    Gemfields (LSE:GEM) said it expects to report a significantly wider net loss for the six months ended 30 June 2026, primarily reflecting a non-cash impairment relating to its Montepuez Ruby Mining operation.

    The impairment follows lower-than-expected recoveries of premium rubies at Montepuez during the period.

    At the same time, revenues from Montepuez and Kagem Mining increased compared with the corresponding period a year earlier, supported in part by deferred ruby auction sales.

    Gemfields also said headline earnings per share for the period were positive. The company is due to provide further financial details when it publishes its interim results.

    Gemfields Reports Improved Recent Ruby Recoveries

    Management said remedial measures have been implemented at Montepuez, including changes relating to mine planning, grade performance and operational reliability.

    According to the company, processing plant PP2 has achieved its design throughput, while recent ruby recoveries have improved. Gemfields said its focus for the remainder of 2026 will be on establishing whether these improvements can be sustained while maintaining financial discipline.

    The company is scheduled to release its interim results and discuss them during a webcast on 30 September 2026.

    About Gemfields Group

    Gemfields Group Limited is a Guernsey-incorporated gemstone producer with shares traded on London’s AIM and the Johannesburg Stock Exchange.

    The company owns 75% of Kagem Mining in Zambia, which produces emeralds, and 75% of Montepuez Ruby Mining in Mozambique. Gemfields also holds other gemstone licences in Africa.

    The group uses its own gemstone grading system and auction platform for the sale of emeralds and rubies to downstream markets.

  • SEIT Calls General Meeting on Board Appointments for Wind-Down

    SEIT Calls General Meeting on Board Appointments for Wind-Down

    SDCL Energy Efficiency Income Trust plc (LSE:SEIT) has called a general meeting for 15 October to seek shareholder approval for the appointment of Boaz Weinstein and Richard Pavry as non-executive directors.

    Weinstein and Pavry have been nominated by the investment trust’s two largest shareholders, Saba Capital Management and General Atlantic, respectively.

    If approved, both would serve as non-independent non-executive directors and would not receive fees for their roles.

    Governance Measures Planned for Proposed Directors

    SEIT said governance arrangements are planned to address potential conflicts of interest arising from the appointments and to protect confidential information relating to asset disposals.

    The proposed appointments follow the trust’s decision in July to adopt a wind-down investment objective. Under the revised approach, SEIT is seeking to realise its portfolio through an orderly sale of assets and return capital to shareholders.

    The board said representation from the trust’s two largest shareholders would provide alignment during the wind-down process.

    SEIT’s board has unanimously recommended that shareholders vote in favour of both appointments. Saba Capital Management and General Atlantic have also committed to vote their respective holdings in favour of both resolutions.

    About SDCL Energy Efficiency Income Trust

    SDCL Energy Efficiency Income Trust plc is a London-listed investment company with a portfolio of energy efficiency and decentralised energy assets.

    Following the change to its investment objective, the trust is focused on the orderly realisation of its portfolio and the return of capital to shareholders.

  • Tharisa Places US$300 Million Nordic Bond Proceeds in Escrow for Karo Platinum Project

    Tharisa Places US$300 Million Nordic Bond Proceeds in Escrow for Karo Platinum Project

    Tharisa (LSE:THS) said the net proceeds from its US$300 million five-year senior secured Nordic bond have been placed in escrow following the satisfaction of a condition precedent.

    The bond was issued through the company’s subsidiary, Arxo Finance, and carries an 11.00% semi-annual coupon. It was priced at 98% of its principal amount and was oversubscribed.

    The proceeds will remain in escrow until the remaining conditions for their release to the group have been satisfied.

    Bond Proceeds to Fund Karo Platinum Project

    Tharisa said the financing will be used to complete the Karo Platinum Project in Zimbabwe, where the company is targeting first ore to the mill during the fourth quarter of 2027.

    The placement of the proceeds in escrow follows the completion of one of the conditions required under the bond financing. Release of the funds remains subject to the outstanding conditions being met.

    The company did not provide further details in the supplied information on the remaining conditions or their expected completion date.

    About Tharisa

    Tharisa is an integrated mining and metals group focused on platinum group metals and chrome concentrates. Its activities include exploration, mining, processing, beneficiation, marketing, sales and logistics.

    The group operates the Tharisa Mine in South Africa and is developing the Karo Platinum Project in Zimbabwe. It is also investing in downstream beneficiation and energy-storage technologies.

  • Young & Co.’s CEO Simon Dodd to Join Hollywood Bowl as Non-Executive Director

    Young & Co.’s CEO Simon Dodd to Join Hollywood Bowl as Non-Executive Director

    Young & Co.’s Brewery (LSE:YNGA) said Chief Executive Officer Simon Dodd will join Hollywood Bowl plc (LSE:BOWL) as an independent non-executive director from 1 November 2026.

    The appointment will see Dodd take on the external board position alongside his existing responsibilities as chief executive of Young’s.

    Young’s Board Reviews External Appointment

    According to Young’s, its board considered the appointment following a review by the nominations committee.

    The board concluded that the non-executive position at Hollywood Bowl would complement Dodd’s existing role and provide additional strategic and governance experience without affecting his responsibilities as chief executive of Young’s.

    Hollywood Bowl is a listed leisure operator, giving Dodd an additional board position within the UK leisure sector.

    About Young & Co.’s Brewery

    Young & Co.’s Brewery P.L.C. is a London-based pub company operating in the UK leisure and hospitality sector. The company focuses on managed pubs and associated customer experiences.

  • Wall Street Futures Decline as 10-Year Treasury Yield Reaches Highest Since 2007: Dow Jones, S&P, Nasdaq

    Wall Street Futures Decline as 10-Year Treasury Yield Reaches Highest Since 2007: Dow Jones, S&P, Nasdaq

    U.S. equity futures traded lower on Thursday as the benchmark 10-year Treasury yield reached its highest level since July 2007 and oil prices extended their rebound.

    The 30-year Treasury yield also moved higher, reaching its highest level since 2004, following a broader increase in government bond yields during the previous session.

    U.S. crude oil futures rose nearly 2% after gaining 1.8% on Wednesday, when crude ended a five-session losing streak.

    The moves came as investors assessed developments in the Middle East, expectations for Federal Reserve monetary policy and an upcoming meeting between U.S. President Donald Trump and Chinese President Xi Jinping.

    Oil Rebounds as Markets Assess U.S.-Iran Talks

    Oil markets remained focused on the prospects for diplomatic progress between the United States and Iran.

    Expectations that talks could contribute to an easing of tensions had been among the factors accompanying lower crude prices earlier in the week. Prices subsequently rebounded as uncertainty over the negotiations continued.

    The latest moves followed remarks by Trump and Iranian President Masoud Pezeshkian at the United Nations General Assembly.

    Trump threatened to “annihilate” Iran if an agreement was not reached, while also discussing the possibility of further negotiations.

    Pezeshkian criticised what he called “signs of a bullying mentality” from the United States and said Iran would not surrender.

    The comments represented the positions of the respective leaders as negotiations continued and did not establish the outcome of future diplomatic discussions.

    Trump-Xi Meeting Adds Another Focus for Markets

    Separately, Trump and Xi are scheduled to meet at the White House on Thursday, with trade, artificial intelligence and critical minerals expected to be among the subjects discussed.

    The meeting comes as Washington and Beijing continue negotiations over their economic relationship.

    U.S. Treasury Secretary Scott Bessent has announced an extension of the existing trade truce between the two countries, providing additional time for negotiations.

    The extension delays the expiry of the current arrangements but does not determine whether a broader agreement will be reached.

    Nasdaq Drops 1.1% in Wednesday Session

    Thursday’s lower futures followed declines across all three major U.S. indexes on Wednesday.

    The Nasdaq Composite recorded the largest percentage decline, falling 308.24 points, or 1.1%, to 26,936.04.

    The S&P 500 declined 58.61 points, or 0.8%, to 7,706.03, while the Dow Jones Industrial Average dropped 352.10 points, or 0.7%, to 51,511.59.

    The indexes closed near their session lows as investors assessed rising oil prices, higher bond yields and the outlook for monetary policy.

    Gold also declined on Wednesday as the U.S. dollar remained firm and markets reassessed expectations for further Federal Reserve interest-rate changes.

    September PMIs Come in Above Forecasts

    U.S. economic data added to the information being considered by investors.

    Preliminary September S&P Global purchasing managers’ indexes for manufacturing, services and composite activity all exceeded expectations, according to the information provided.

    The readings contributed to market discussion over the Federal Reserve’s next policy steps. They do not, however, determine future interest-rate decisions, which will depend on policymakers’ assessment of incoming economic data.

    Energy-market data also drew attention after the U.S. Energy Information Administration reported an increase of almost 3 million barrels in crude inventories during the latest week. Markets had expected inventories to decline.

    U.S. stock futures remained lower ahead of Thursday’s opening as investors monitored developments in bond, energy and currency markets alongside the U.S.-Iran and U.S.-China discussions.

  • European Stocks Edge Lower as Brent Crude Holds Above $100: DAX, CAC, FTSE100

    European Stocks Edge Lower as Brent Crude Holds Above $100: DAX, CAC, FTSE100

    European stock markets traded mostly lower on Thursday as Brent crude futures remained above $100 a barrel, while investors assessed interest-rate expectations and the forthcoming meeting between U.S. President Donald Trump and Chinese President Xi Jinping.

    France’s CAC 40 was down 0.3%, while Germany’s DAX declined 0.2%. The UK’s FTSE 100 moved in the opposite direction, gaining 0.1%.

    Oil prices remained a focus for markets amid continuing tensions in the Middle East. Expectations for U.S. monetary policy were also in focus following Federal Reserve commentary and recent economic data.

    Trump and Xi Meeting in Washington

    Trump and Xi are due to hold talks at the White House on Thursday, with trade, artificial intelligence and critical minerals among the issues expected to be discussed. The meeting comes during Xi’s visit to Washington and amid ongoing negotiations between the United States and China.

    Ahead of the meeting, U.S. Treasury Secretary Scott Bessent said the two countries had agreed to extend their trade truce by two months. The agreement, previously due to expire on November 10, will now run until January 10, providing additional time for negotiations over a broader economic arrangement.

    The extension postpones the scheduled expiry of the existing tariff truce but does not by itself establish that the two governments will reach a broader trade agreement.

    European Automakers Move Lower

    Mercedes-Benz (LSE:MBG) shares moved lower following reports that the automaker plans to reduce labour costs in Germany by €800 million.

    Renault (EU:RNO), Volkswagen (LSE:VOW3) and BMW (TG:BMW) also declined despite EU new passenger-car registrations increasing 4.5% year-on-year in August.

    The information supplied does not establish that the latest registration figures were the sole factor affecting individual automaker shares.

    Carbios and H&M Shares Decline

    French biotechnology company Carbios (EU:ALCRB) fell after reporting a first-half net loss of €9.43 million.

    Swedish fashion retailer H&M also declined despite reporting a larger-than-expected increase in third-quarter operating profit.

    Johnson Matthey (LSE:JMAT) traded lower after the British speciality chemicals and sustainable technologies company announced plans to begin a share repurchase programme with a maximum consideration of £200 million.

    Shelly Group Rises on Schneider Electric Bid Plans

    Shelly Group (TG:SLYG) shares advanced after Schneider Electric (EU:SU) announced plans to launch a €1.2 billion ($1.4 billion) offer to acquire the Bulgarian smart-home device company.

    The proposed transaction remains subject to the terms and completion conditions associated with the acquisition process.

    Overall, European equities were mostly lower during Thursday’s session, with energy prices, interest-rate expectations, corporate developments and the U.S.-China talks among the issues being monitored by investors.

  • UK Retailers Report Record Cut in Supplier Orders as Sales Decline, CBI Says

    UK Retailers Report Record Cut in Supplier Orders as Sales Decline, CBI Says

    UK retailers reported a further decline in sales volumes in September and reduced orders placed with suppliers at the fastest rate since the Confederation of British Industry’s survey began in 1983, according to the latest CBI Distributive Trades Survey.

    The CBI’s headline distributive trades balance, which measures reported activity compared with a year earlier, fell to -55 in September from -48 in August.

    Martin Sartorius, lead economist at the CBI, said retailers reported a substantial year-on-year decline in sales volumes during the month, with some respondents attributing the deterioration to consumer sentiment.

    “The persistent sales downturn appears to have prompted retailers to cut back on order volumes at a survey-record pace,” Sartorius said.

    The record relates to responses in the CBI survey and does not represent a measure of the absolute value of orders across the entire UK retail sector.

    Wholesalers and Motor Traders Also Report Lower Sales

    The survey indicated that weaker activity extended beyond retailers, with wholesalers and motor traders also reporting declining sales.

    Retailers’ expectations for sales volumes were also negative, with the relevant balance reported at -37 compared with -22 previously.

    The CBI said it hoped the government’s growth agenda would include lower property taxes for high-street retailers.

    The organisation’s comments represent its policy position on measures affecting the retail sector rather than a finding from the survey itself.

    CBI Survey Differs From Official Retail Sales Data

    The CBI’s retail indicators have recently presented a more negative picture than some other measures of the UK retail sector, including data from the British Retail Consortium and the Office for National Statistics.

    The ONS’s official retail-sales figures use a different methodology and therefore are not directly equivalent to the CBI’s survey balances.

    Official ONS data released in September showed continued year-on-year growth in retail sales volumes excluding automotive fuel. The CBI survey, by contrast, measures the balance between businesses reporting increases and decreases in activity.

    The latest CBI survey was based on responses from 46 retail chains and 71 wholesalers collected between August 27 and September 14.