Author: Fiona Craig

  • Genflow Reports Interim SIRT6c Data From Ageing Dog Study

    Genflow Reports Interim SIRT6c Data From Ageing Dog Study

    Genflow Biosciences (LSE:GENF) has reported interim results from its SLAB-VET-001 canine study evaluating its centenarian-derived SIRT6c gene therapy in aged Beagles.

    The blinded study involves 24 dogs divided across four treatment arms and is evaluating SIRT6c delivered using either plasmid DNA or AAV8, with saline used as the control.

    Genflow said the treatments were generally well tolerated, with no treatment-related serious adverse events or systemic inflammatory responses observed across the study arms at the interim assessment.

    At Day 182, analysis of the study’s primary endpoint showed the largest mean reductions in epigenetic age among animals in the plasmid DNA treatment groups. The company said most dogs receiving plasmid DNA had lower biological ages compared with their respective baseline measurements.

    However, differences between the treatment groups and the control group did not reach statistical significance at this stage of the study.

    Histological analysis indicated preserved muscle structure and signs of activated muscle regeneration in treated animals, according to Genflow. Ultrasound assessments also indicated greater increases in muscle mass in the high-dose plasmid DNA and AAV8 groups.

    Based on the interim findings, Genflow has selected intravenous plasmid DNA as its lead delivery method for the veterinary SIRT6c programme.

    The company has also extended the study to include a Day 320 assessment, providing a longer follow-up period for evaluating the treatment.

    Genflow said it is considering potential commercialisation options for the veterinary programme, including an asset sale or a risk-sharing licensing agreement with animal health companies.

    More about Genflow Biosciences

    Genflow Biosciences Plc is a biotechnology company developing gene therapies targeting biological processes associated with ageing.

    Its programmes are based on SIRT6c, a variant of the SIRT6 gene identified in centenarians. The company is developing SIRT6c for human applications using mRNA-LNP delivery, including programmes targeting metabolic dysfunction-associated steatohepatitis and ophthalmology, alongside its veterinary programme in ageing dogs.

    Genflow is listed on the London Stock Exchange and the U.S. OTCQB market.

  • Neo Energy Metals Advances New Beisa and Henkries Projects During Third Quarter

    Neo Energy Metals Advances New Beisa and Henkries Projects During Third Quarter

    Neo Energy Metals (LSE:NEO) reported progress across its New Beisa and Henkries uranium projects during the third quarter, alongside changes to its management team and a £1.75 million fundraising.

    The company said it continued to progress regulatory approvals relating to New Beisa and Henkries while limiting expenditure ahead of securing full ownership of the New Beisa project.

    At New Beisa, Neo Energy completed an updated stope inventory using optimisation work as part of its technical planning for the project. The company also initiated an implementation assessment covering processing facilities and infrastructure in preparation for the transfer of mining rights.

    Work also continued at the Henkries uranium project in South Africa’s Northern Cape, where Neo Energy advanced mine design activities alongside environmental, regulatory and technical workstreams.

    The company said these activities form part of its preparations for the potential future development of the projects, subject to the necessary ownership transfers, regulatory approvals and other requirements.

    Neo Energy also announced management changes during the quarter, appointing mining executive Elmarié Maritz as chief financial officer.

    Martin Westerman, who previously served as acting CFO, moved into a new position overseeing operations and project delivery.

    The company also raised £1.75 million during the period. Neo Energy said the proceeds are intended to provide working capital and support ongoing regulatory processes.

    In addition, the group continued work on its corporate governance framework as it progresses the development and regulatory processes associated with its uranium portfolio.

    More about Neo Energy Metals

    Neo Energy Metals plc is a mining company listed in London and on South Africa’s A2X market, with a focus on uranium and associated metals.

    Its principal assets include the New Beisa project within the Beatrix 4 Shaft Mining Area and the Henkries uranium project in South Africa’s Northern Cape.

    The company is progressing mine design, technical, environmental and regulatory work relating to the projects as it works towards their potential future development.

  • Pulsar Helium Contracts Airborne Survey for Falcon Project in Michigan

    Pulsar Helium Contracts Airborne Survey for Falcon Project in Michigan

    Pulsar Helium (LSE:PLSR) has signed a contract with Xcalibur MPH (Canada) to conduct a high-resolution airborne gravity gradiometry and magnetic survey at its Falcon helium project in Michigan’s Upper Peninsula.

    The planned survey will cover approximately 14,727 line kilometres across a priority area of the project. Closely spaced survey and tie lines will be used to collect data on subsurface density contrasts, lithological boundaries and geological structures.

    Pulsar said the survey data will be combined with a recently released magnetic and radiometric dataset from the U.S. Geological Survey’s Earth MRI programme, which covers a substantial portion of the Falcon land position.

    The USGS dataset is available to Pulsar at no cost, according to the company.

    Pulsar intends to use the combined datasets to improve its understanding of the Precambrian basement geology across the project area. The information will also be used to identify and rank potential helium targets and inform future drilling decisions.

    The company said the work represents a move from land assembly towards systematic target generation at Falcon. Its exploration approach at the project is based on the geological model being applied at its Topaz helium project in Minnesota.

    More about Pulsar Helium

    Pulsar Helium Inc. is a primary helium exploration company with listings on London’s AIM, Canada’s TSX Venture Exchange and the U.S. OTCQB.

    Its portfolio comprises the Topaz project in Minnesota, the Falcon project in Michigan and the Tunu project in Greenland. The company focuses on exploration for primary helium occurrences that are not associated with hydrocarbon production.

  • Sirius Real Estate Reports 11.3% Increase in Half-Year Rent Roll

    Sirius Real Estate Reports 11.3% Increase in Half-Year Rent Roll

    Sirius Real Estate (LSE:SRE) reported an 11.3% year-on-year increase in its rent roll for the six months ended 30 September 2026, supported by acquisitions and organic growth across its German and UK operations.

    Like-for-like rent roll increased 5.1%, with the company reporting similar levels of organic growth in Germany and the UK.

    During the period, Sirius invested approximately €150 million in acquisitions at gross yields above 8%. The purchases included German business parks with defence-related companies among their occupiers.

    The property group also expanded its self-storage operations and continued to rationalise smaller properties in its UK portfolio. Proceeds from asset recycling are being directed towards larger properties where the company sees opportunities for additional investment and asset management.

    Sirius also made changes to its debt structure during the half year. The company repaid a €400 million bond and increased the size of its bonds due in 2028 and 2032 to benchmark levels.

    Following these transactions, the group reported available liquidity of more than €250 million.

    Management said it remains confident in the company’s ability to deliver double-digit total returns over the longer term, alongside rental growth and a well-covered dividend. These remain management objectives rather than guaranteed future outcomes.

    More about Sirius Real Estate

    Sirius Real Estate is listed in London and Johannesburg and owns and operates business and industrial parks in Germany and the UK.

    The company’s portfolio comprises 145 assets serving more than 10,000 tenants. It provides conventional and flexible workspace through its Sirius and BizSpace brands.

    Its strategy includes acquiring properties and seeking to increase their value through asset management, while selectively selling mature assets and reallocating capital to other properties.

  • Symphony Environmental Says Colombia Accepts d2w Evidence for Polyethylene Films and Bags

    Symphony Environmental Says Colombia Accepts d2w Evidence for Polyethylene Films and Bags

    Symphony Environmental Technologies (LSE:SYM) said Colombia’s Ministry of Environment has accepted scientific evidence supporting the use of its d2w masterbatch in polyethylene films and bags under the country’s single-use plastics legislation.

    The decision follows an earlier recognition relating to the use of d2w technology in polypropylene drinking straws.

    According to Symphony, the latest determination allows Colombian producer E.H.G. Color Plast to market polyethylene films and bags incorporating d2w as biodegradable products rather than being subject to restrictions under the legislation.

    The company said applications involving d2w products from other manufacturers are also being reviewed by Colombian authorities.

    Symphony said evidence submitted in support of the application included testing to ASTM D6954 carried out by Intertek, an ISO 17025-accredited laboratory. The company also cited independent studies relating to the biodegradation characteristics of plastics incorporating d2w and the presence of microplastics.

    Colombia consumes approximately 1.3 million tonnes of plastic annually, according to the information provided by Symphony.

    The company is seeking to expand the use of its d2w technology in Colombia as well as other markets in Latin America and internationally.

    More about Symphony Environmental Technologies

    Symphony Environmental Technologies develops technologies and additives for plastic products, with its portfolio including d2w biodegradable plastic technology, d2p protective additives, d2t marker technologies and NbR materials.

    The UK-based company distributes its products through more than 70 partners across nearly 100 countries and holds ISO and Green Economy certifications.

  • Bradda Head Reports Spodumene-Bearing Pegmatite Intercepts at Whistlejacket

    Bradda Head Reports Spodumene-Bearing Pegmatite Intercepts at Whistlejacket

    Bradda Head Lithium Ltd (LSE:BHL) has reported visible spodumene mineralisation from the first three diamond drill holes completed as part of its maiden drilling programme at the Whistlejacket lithium project in Arizona.

    The company said holes WSTL0020, WSTL0021 and WSTL0022 intersected broad pegmatite intervals containing fresh spodumene crystals. Drilling of a fourth hole is underway, while core from the first three holes has been sent for laboratory analysis.

    Whistlejacket is being explored under an option-to-joint-venture agreement with Kennecott Exploration Company.

    Bradda Head said the mineralised intervals encountered in the initial drilling, particularly in WSTL0020 and WSTL0022, were consistent with previous work carried out by Kennecott.

    Earlier work at the project indicated lithium deportment to spodumene and produced Dense Media Separation results that the company considers relevant to further metallurgical testing. Bradda Head plans additional testwork focused on the potential production of a spodumene concentrate.

    Approximately 24 holes are planned at Whistlejacket during 2026. The programme is intended to provide additional information on the three-dimensional geometry of the project’s principal mineralised body.

    Whistlejacket covers nine Arizona State mineral exploration permits. Kennecott previously completed 19 diamond holes at the project, with lithium mineralisation reported in all of those holes.

    The project forms part of Bradda Head’s Arizona portfolio alongside its Basin and San Domingo lithium projects.

    At Basin East, the company reports a combined Measured, Indicated and Inferred resource of 2.81 million tonnes of lithium carbonate equivalent. Permitting work is also underway at Basin West.

    At San Domingo, Bradda Head has completed 108 drill holes across three drilling campaigns and mapped more than 1,000 pegmatites. The company has identified priority pegmatite targets for additional exploration, with further drilling dependent on permit approvals. The work is intended to support a future NI 43-101 resource estimate.

    Bradda Head is focused on lithium projects in the United States, including pegmatite and clay-hosted assets. In addition to its three principal Arizona projects, the company is exploring other pegmatite and brine prospects in Arizona, Nevada and Pennsylvania.

  • 1947 Oil & Gas Builds Growth Strategy Around Producing Assets and Acquisition Platform

    1947 Oil & Gas Builds Growth Strategy Around Producing Assets and Acquisition Platform

    1947 Oil & Gas (LSE:1947) is building its growth strategy from an operating base, with the recently acquired Renaissance business providing immediate production, cash flow and a platform for further expansion in the Gulf of America.

    For newly listed oil and gas companies, the journey from listing to production can often take considerable time. 1947 Oil & Gas is taking a different approach, beginning its growth story with producing assets already in place.

    Following its acquisition of Renaissance, the company has an immediate production base of approximately 3,000 barrels of oil equivalent per day across 11 fields, giving 1947 a foundation from which it can pursue its longer-term consolidation strategy.

    Speaking on the ADVFN Watch List, 1947 Oil & Gas co-founder and President Ivan Murphy highlighted the significance of starting with a business that is already producing, selling oil and generating cash flow.

    “We are producing oil, selling oil, and making money right now,” Murphy said, underlining the company’s focus on building from an established operating platform.

    Building from an established production base

    The Renaissance acquisition gives 1947 an experienced operational team alongside its existing production base, with the company now looking to build scale through additional acquisitions.

    Murphy said the opportunity across the shallow-water Gulf of America is particularly attractive, with 1947 targeting smaller producing opportunities that can be added incrementally to the existing portfolio.

    The strategy is to build production through a series of acquisitions, potentially adding assets producing several thousand barrels per day at a time.

    Over the next few years, the company is targeting a potential production level of 25,000–35,000 barrels of oil equivalent per day, representing a significant expansion from its current platform.

    Rather than relying on a single transformational acquisition, the approach is centred on consolidating a large and established producing region through a series of complementary transactions.

    A clean balance sheet provides acquisition flexibility

    An important feature of the starting position is that 1947 has no acquisition debt and no hedging in place, while the underlying business is cash-flow positive.

    That gives the company flexibility as it looks to pursue further opportunities.

    Murphy explained that the existing assets can provide a platform from which the company can use a reasonable level of asset-backed financing to support future acquisitions, while also using additional EBITDA generated by those assets to help fund subsequent growth.

    The potential benefit is a compounding model: acquire producing assets, generate additional cash flow and EBITDA, and then use the enlarged platform to pursue further opportunities.

    Starting without acquisition debt also gives 1947 greater financial flexibility as it evaluates potential transactions.

    Targeting a prolific oil-producing region

    The company’s strategy is focused on the Gulf of America, a region with a long-established conventional oil and gas industry and significant existing infrastructure and expertise.

    For 1947, this provides the opportunity to pursue assets where production is already established rather than taking on the development risk associated with building a business entirely from undeveloped resources.

    The Renaissance team also brings experience of managing the acquired assets, providing continuity as 1947 looks to expand the portfolio.

    Murphy described the team as an important part of the company’s platform and said the group is now excited about using 1947’s capital and new ownership structure to pursue further consolidation.

    A platform for further growth

    The combination of existing production, positive cash flow, an experienced operating team and a debt-free acquisition starting point provides 1947 Oil & Gas with the foundations for its next stage of development.

    The company’s ambition is clear: to use Renaissance as the base for a broader consolidation strategy, adding producing assets across the Gulf of America and progressively increasing production.

    For investors, the key part of the strategy is that the growth plan starts with an operating business rather than a purely future production proposition.

    With approximately 3,000 barrels of oil equivalent per day already being produced and further acquisitions forming a central part of the company’s plans, 1947 is seeking to create a larger, diversified producing platform through disciplined consolidation.

    As Murphy put it, the objective is to be producing, generating cash flow and positioned to take advantage of further opportunities in the US oil and gas market.

    With Renaissance providing the initial platform, the next phase for 1947 Oil & Gas will be focused on executing that acquisition strategy and building scale.

    For more information visit – https://1947plc.com/

  • Pathos Communications: AI and Pay-on-Results Model Open Up a Global Growth Opportunity

    Pathos Communications: AI and Pay-on-Results Model Open Up a Global Growth Opportunity

    Pathos Communications (LSE:NEWS) is positioning itself for further growth by combining a pay-on-results approach to media coverage with proprietary AI technology, opening access to PR services for a much broader international customer base.

    The company’s growth opportunity was highlighted in a recent Financial Times feature, with Pathos recognised as the UK’s fastest-growing business in its sector.

    Speaking on the ADVFN Watch List, Pathos Communications CEO Omar Hamdi outlined how the company is changing the traditional PR model and using technology to make media coverage more accessible, scalable and measurable.

    Changing the traditional PR model

    For many smaller businesses, securing meaningful media coverage can be challenging. Traditional PR services can involve significant retainers, with companies paying upfront for the opportunity to generate coverage without certainty over the results.

    Pathos is taking a different approach.

    Its pay-on-results model is designed to align the cost of PR with the delivery of outcomes, potentially making professional media exposure accessible to businesses that may otherwise be reluctant to commit to a traditional PR retainer.

    Hamdi explained that Pathos has been working to take many of the tasks traditionally delivered by a small team of highly experienced PR professionals and “virtualize” them through processes, tooling and technology.

    That approach is allowing the company to address a much larger potential market.

    According to Hamdi, the global opportunity extends across hundreds of millions of small and medium-sized businesses, many of which have a story to tell but may not want to commit to the cost and uncertainty associated with conventional PR.

    Proprietary AI creates scalability

    A key part of the Pathos growth story is its use of proprietary AI technology.

    By combining technology with established PR processes, the company is looking to make its service more scalable while maintaining a focus on delivering measurable results for clients.

    This creates an opportunity to expand beyond the traditional PR agency model, with technology helping Pathos serve a larger number of businesses across multiple markets.

    The timing is also significant as businesses increasingly recognise that media coverage can play a role far beyond traditional brand awareness.

    PR becomes increasingly important in the AI era

    One of the most interesting areas highlighted by Hamdi is the changing relationship between PR, search and artificial intelligence.

    He described Generative Engine Optimisation (GEO) as an important emerging opportunity, arguing that “PR is the new SEO” as businesses look to improve their visibility across AI-powered search and answer platforms.

    As AI systems increasingly provide users with answers based on information available across the internet, being referenced by credible third-party media can become an important component of digital visibility.

    Hamdi cited an estimate that a significant proportion of citations used by AI platforms originate from PR and media coverage, highlighting what could become an increasingly important market opportunity for businesses seeking to establish their authority online.

    For Pathos, this potentially expands the role of media coverage from simply generating publicity to helping businesses build a stronger digital footprint in an increasingly AI-driven online environment.

    International expansion

    Pathos is already operating internationally, with Hamdi stating that the company has clients in around 90 countries.

    The next phase of growth is expected to include a greater focus on international markets, with the Asia-Pacific region identified as a particular area of opportunity.

    The company has established an APAC team and is looking to build on the progress already being made in the region.

    International expansion provides another potential growth driver as businesses around the world increasingly seek cost-effective ways to communicate their stories, attract customers and establish credibility.

    A large addressable market

    The underlying opportunity for Pathos is supported by a continual flow of potential customers.

    Businesses are launched, raise capital and enter periods of growth every year. Each of these milestones creates a potential need for communications and media exposure.

    Pathos believes its model can appeal particularly strongly to companies that want the benefits of PR but remain cautious about committing to large upfront retainers.

    By linking its commercial model more closely to results and using proprietary technology to increase scalability, the company is seeking to broaden the addressable market for its services.

    Building on growth

    For Pathos Communications, the combination of AI, a pay-on-results commercial model and international expansion provides three important pillars for its next stage of development.

    The recognition from the Financial Times provides further visibility around the company’s growth, while the opportunity to serve a much larger SME market gives Pathos significant scope to continue expanding.

    With businesses increasingly competing for visibility across traditional search engines, social platforms and AI-powered services, the importance of credible media coverage is also evolving.

    Pathos is positioning itself at the intersection of these trends, using technology to make PR more accessible while seeking to deliver measurable outcomes for clients.

    With an established international customer base, continued investment in its AI platform and an expanding presence in markets such as APAC, the company sees significant opportunities ahead as it works to scale its model globally.

    For more information visit https://pathoscommunicationsplc.com/

  • Buccaneer Energy Targets US Production Growth and European Gas Expansion

    Buccaneer Energy Targets US Production Growth and European Gas Expansion

    CEO Paul Welch outlines the company’s return to profitability, progress across its US portfolio and plans to secure a European gas opportunity by year-end.

    Buccaneer Energy (LSE:BUCE) is pursuing growth on two fronts, combining opportunities to increase production from its existing US assets with an ambitious strategy to expand into European gas markets.

    In a new episode of The Watch List, CEO Paul Welch discussed the company’s interim results, its priorities for the second half of 2026 and why the European strategy is expected to become a major driver of growth over the next 12 to 24 months.

    Return to Profitability Provides Momentum

    Buccaneer Energy returned to profitability in the first half of 2026, a result Welch highlighted as particularly encouraging given the challenging commodity pricing environment during the opening months of the period.

    With prices recovering as the year progressed, the company delivered a profitable first half while continuing to advance its operational and strategic priorities.

    Looking ahead, Welch identified European gas as a central part of Buccaneer’s growth plans, with the company moving quickly to progress opportunities that could broaden its business beyond its established US production portfolio.

    European Gas Strategy Opens a New Growth Opportunity

    Welch explained that Buccaneer is targeting European gas opportunities that have remained largely untouched for an extended period, applying modern technology to opportunities that could benefit from a fresh approach.

    The strategy is underpinned by the prevailing energy pricing environment, with Welch highlighting prices of around $150 per barrel on an energy-equivalent basis as an illustration of the potential value of the market.

    The company is now focused on advancing these opportunities, with the ambition of securing at least one European gas opportunity by the end of 2026.

    While Welch acknowledged that completing a deal within this timeframe would be challenging, he made clear that the company is pushing hard to achieve this milestone.

    Success would give Buccaneer an additional avenue for growth and establish a new strategic dimension alongside its existing US operations.

    US Assets Remain Central to Production Growth

    Alongside its European ambitions, Buccaneer continues to focus on extracting further value from its existing portfolio.

    One of the key operational priorities is production growth from the company’s Fouke waterflood project. Welch confirmed that the area has recently been mapped and that the company is progressing the next steps, including negotiations with its partners.

    Waterflood projects can help improve recovery from existing oil reservoirs by injecting water to support reservoir pressure and drive additional oil towards producing wells. The planned work at Fouke therefore represents an important area to watch as Buccaneer seeks to build on its existing production base.

    The timing and scale of any resulting production gains will depend on the project’s development and the completion of the necessary partner discussions.

    Two Key Milestones for the Second Half of 2026

    Welch outlined two broad priorities for the remainder of the year: advancing production growth from Fouke and securing at least one European gas opportunity.

    Both initiatives have the potential to contribute to the company’s next phase of development, although they remain subject to operational progress, negotiations and successful execution.

    The combination of these priorities reflects Buccaneer’s approach to growth: developing opportunities within its existing US portfolio while pursuing new markets that could expand its future business.

    Building the Next Phase of Growth

    Buccaneer Energy enters the second half of 2026 with a return to profitability behind it and two clear areas of focus ahead.

    Progress at Fouke offers a route to potential production growth from existing assets, while the European gas strategy could provide access to new opportunities in a market Welch believes offers attractive energy pricing.

    With the company working towards a year-end milestone for its European expansion, the coming months will be important in determining how quickly these plans translate into tangible operational and commercial progress.

    Investors will be watching for further developments across both fronts as Buccaneer seeks to build on its first-half performance and establish the foundations for its next stage of growth.

    For more information, visit buccaneerenergy.co.uk.

  • AI Software Enters ROI Phase as Enterprise Spending Becomes More Selective, Oppenheimer Says

    AI Software Enters ROI Phase as Enterprise Spending Becomes More Selective, Oppenheimer Says

    Enterprise artificial intelligence investment is entering a phase in which measurable financial returns are becoming more important than adoption levels alone, according to Oppenheimer.

    The firm said AI is increasingly being treated as a recurring operating expense, with chief financial officers comparing technology spending with labour costs and requiring clearer evidence of returns on investment.

    This change is leading to greater discipline in AI budgets, according to Oppenheimer. The firm said investors are also increasing their scrutiny of software companies to determine whether adoption of AI products can translate into sustainable growth and financial returns.

    System-of-Record Vendors Among Oppenheimer’s Preferred Exposure

    Oppenheimer said system-of-record software providers and companies using seat-plus-consumption pricing models are positioned to participate in increased AI usage while retaining established customer relationships.

    The firm said Microsoft (NASDAQ:MSFT), Oracle (NYSE:ORCL), Salesforce (NYSE:CRM) and ServiceNow (NYSE:NOW) have each established AI businesses exceeding $1 billion. Workday (NASDAQ:WDAY), meanwhile, is seeing high attachment rates for its AI offerings, according to Oppenheimer.

    Microsoft is among the firm’s preferred stocks, with Oppenheimer citing increasing platform demand, capital allocation and distribution across its installed customer base.

    Oppenheimer also highlighted ServiceNow based on its growth and cash flow generation, medium-term financial targets and exposure to automation and security.

    Braze (NASDAQ:BRZE) was included among the firm’s preferred names based on its role as a system of record for customer engagement and its profitable growth.

    Figma and SoundHound AI Face Different Considerations

    Oppenheimer expressed a more cautious view of Figma. While the firm said the company’s execution remains solid, it expects growth could moderate as the impact of pricing measures diminishes.

    The firm also said Figma’s valuation means additional upside depends on the company continuing to outperform current expectations.

    For SoundHound AI (NASDAQ:SOUN), Oppenheimer cited uncertainty around the timing of a profitability inflection as the company’s end markets become more mature and remain competitive.

    The firm additionally highlighted SoundHound AI’s reliance on mergers and acquisitions to support guidance and its stock-based compensation levels.